دورية أكاديمية
أعرض في EDS

Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors.

التفاصيل البيبلوغرافية
العنوان: Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors.
المؤلفون: Bidinotto LT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal.; Human and Experimental Biology Department, Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, SP 14785 002, Portugal., Véo CAR; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal., Loaiza EA; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal., Ribeiro GG; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal., Lorenzi AT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal., Rosa LAR; Laboratory of Virology, Institute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403 000, Portugal., De Oliveira CM; Laboratory of Virology, Institute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403 000, Portugal., Levi JE; Laboratory of Virology, Institute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403 000, Portugal., Scapulatempo-Neto C; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal.; Department of Pathology, Barretos Cancer Hospital, Barretos, SP 14784 400, Brazil., Longatto-Filho A; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal.; Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga 4704 553, Portugal.; 3B's (Biomaterials, Biodegradables and Biomimetics) Research Group, Portugal Government Associate Laboratory, Braga 4806 909, Portugal., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784 400, Portugal.; Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga 4704 553, Portugal.; 3B's (Biomaterials, Biodegradables and Biomimetics) Research Group, Portugal Government Associate Laboratory, Braga 4806 909, Portugal.
المصدر: Oncology letters [Oncol Lett] 2018 Aug; Vol. 16 (2), pp. 1785-1790. Date of Electronic Publication: 2018 May 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Spandidos Publications] Country of Publication: Greece NLM ID: 101531236 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1792-1074 (Print) Linking ISSN: 17921074 NLM ISO Abbreviation: Oncol Lett Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Athens : Spandidos Publications]
مستخلص: There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients [8 high-grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5-year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5-year disease-free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non-Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV - vs. 5.3% in HPV + patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients.
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فهرسة مساهمة: Keywords: Raf kinase inhibitor protein; adenocarcinoma; anal cancer; high-grade squamous intra-epithelial lesion; squamous-cell carcinoma
تواريخ الأحداث: Date Created: 20180717 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6036404
DOI: 10.3892/ol.2018.8828
PMID: 30008866
قاعدة البيانات: MEDLINE
الوصف
تدمد:1792-1074
DOI:10.3892/ol.2018.8828