دورية أكاديمية
أعرض في EDS

Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review.

التفاصيل البيبلوغرافية
العنوان: Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review.
المؤلفون: de Lima RMT; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Dos Reis AC; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., de Menezes APM; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Santos JVO; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Filho JWGO; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Ferreira JRO; Laboratory of Experimental Cancerology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., de Alencar MVOB; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., da Mata AMOF; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Khan IN; Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan., Islam A; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, Bangladesh., Uddin SJ; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, Bangladesh., Ali ES; Gaco Pharmaceuticals and Research Laboratory, Dhaka-1000, Bangladesh; College of Medicine and Public Health, Flinders University, Bedford Park, Australia., Islam MT; Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Tripathi S; Amity Institute of Microbial Technology, Amity University, Noida, India., Mishra SK; Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar, India., Mubarak MS; Department of Chemistry, The University of Jordan, Amman, Jordan., Melo-Cavalcante AAC; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.
المصدر: Phytotherapy research : PTR [Phytother Res] 2018 Oct; Vol. 32 (10), pp. 1885-1907. Date of Electronic Publication: 2018 Jul 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE
أسماء مطبوعة: Publication: : Chichester : Wiley
Original Publication: London : Heyden & Son, c1987-
مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*pharmacology , Catechols/*pharmacology , Fatty Alcohols/*pharmacology , Zingiber officinale/*chemistry , Neoplasms/*drug therapy , Plant Extracts/*pharmacology, Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Line, Tumor ; Humans ; Inflammation/drug therapy ; Signal Transduction/drug effects
مستخلص: Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger, one of the most ancient known spices, contains bioactive compounds with several health benefits. [6]-Gingerol constitutes the most pharmacologically active among such compounds. The aim of the present work was to review the literature pertaining to the use of ginger extract and [6]-gingerol against tumorigenic and oxidative and inflammatory processes associated with cancer, along with the underlying mechanisms of action involved in signaling pathways. This will shed some light on the protective or therapeutic role of ginger derivatives in oxidative and inflammatory regulations during metabolic disturbance and on the antiproliferative and anticancer properties. Data collected from experimental (in vitro or in vivo) and clinical studies discussed in this review indicate that ginger extract and [6]-gingerol exert their action through important mediators and pathways of cell signaling, including Bax/Bcl2, p38/MAPK, Nrf2, p65/NF-κB, TNF-α, ERK1/2, SAPK/JNK, ROS/NF-κB/COX-2, caspases-3, -9, and p53. This suggests that ginger derivatives, in the form of an extract or isolated compounds, exhibit relevant antiproliferative, antitumor, invasive, and anti-inflammatory activities.
(© 2018 John Wiley & Sons, Ltd.)
فهرسة مساهمة: Keywords: [6]-gingerol; anticancer activity; ginger extract; mechanism of action
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antineoplastic Agents, Phytogenic)
0 (Catechols)
0 (Fatty Alcohols)
0 (Plant Extracts)
925QK2Z900 (gingerol)
تواريخ الأحداث: Date Created: 20180717 Date Completed: 20181031 Latest Revision: 20240109
رمز التحديث: 20240109
DOI: 10.1002/ptr.6134
PMID: 30009484
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-1573
DOI:10.1002/ptr.6134