دورية أكاديمية
أعرض في EDS

Neural mechanisms supporting the relationship between dispositional mindfulness and pain.

التفاصيل البيبلوغرافية
العنوان: Neural mechanisms supporting the relationship between dispositional mindfulness and pain.
المؤلفون: Zeidan F; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, United States., Salomons T; Department of Psychology, School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Farris SR; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, United States., Emerson NM; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, United States., Adler-Neal A; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, United States., Jung Y; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, United States., Coghill RC; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, United States.; Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
المصدر: Pain [Pain] 2018 Dec; Vol. 159 (12), pp. 2477-2485.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: Brain Mapping* , Mindfulness* , Neural Networks, Computer*, Pain/*diagnostic imaging , Pain/*psychology, Adult ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Oxygen/blood ; Pain Management ; Pain Threshold/physiology ; Psychophysics ; Visual Analog Scale ; Young Adult
مستخلص: Interindividual differences in pain sensitivity vary as a function of interactions between sensory, cognitive-affective, and dispositional factors. Trait mindfulness, characterized as the innate capacity to nonreactively sustain attention to the present moment, is a psychological construct that is associated with lower clinical pain outcomes. Yet, the neural mechanisms supporting dispositional mindfulness are unknown. In an exploratory data analysis obtained during a study comparing mindfulness to placebo analgesia, we sought to determine whether dispositional mindfulness is associated with lower pain sensitivity. We also aimed to identify the brain mechanisms supporting the postulated inverse relationship between trait mindfulness and pain in response to noxious stimulation. We hypothesized that trait mindfulness would be associated with lower pain and greater deactivation of the default mode network. Seventy-six meditation-naive and healthy volunteers completed the Freiburg Mindfulness Inventory and were administered innocuous (35°C) and noxious stimulation (49°C) during perfusion-based functional magnetic resonance imaging. Higher Freiburg Mindfulness Inventory ratings were associated with lower pain intensity (P = 0.005) and pain unpleasantness ratings (P = 0.005). Whole brain analyses revealed that higher dispositional mindfulness was associated with greater deactivation of a brain region extending from the precuneus to posterior cingulate cortex during noxious heat. These novel findings demonstrate that mindful individuals feel less pain and evoke greater deactivation of brain regions supporting the engagement sensory, cognitive, and affective appraisals. We propose that mindfulness and the posterior cingulate cortex should be considered as important mechanistic targets for pain therapies.
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معلومات مُعتمدة: K99 AT008238 United States AT NCCIH NIH HHS; F30 AT009165 United States AT NCCIH NIH HHS; R21 AT007247 United States AT NCCIH NIH HHS; F32 AT006949 United States AT NCCIH NIH HHS; R01 AT009693 United States AT NCCIH NIH HHS; R00 AT008238 United States AT NCCIH NIH HHS; L30 AT006838 United States AT NCCIH NIH HHS
المشرفين على المادة: S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20180718 Date Completed: 20190219 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC6237620
DOI: 10.1097/j.pain.0000000000001344
PMID: 30015711
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6623
DOI:10.1097/j.pain.0000000000001344