دورية أكاديمية
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GLP-1 neurons form a local synaptic circuit within the rodent nucleus of the solitary tract.

التفاصيل البيبلوغرافية
العنوان: GLP-1 neurons form a local synaptic circuit within the rodent nucleus of the solitary tract.
المؤلفون: Card JP; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania., Johnson AL; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania.; Systems Neuroscience Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Llewellyn-Smith IJ; Cardiovascular Medicine, Human Physiology and Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia., Zheng H; Department of Psychology, Florida State University, Tallahassee, Florida., Anand R; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom., Brierley DI; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom., Trapp S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom., Rinaman L; Department of Psychology, Florida State University, Tallahassee, Florida.
المصدر: The Journal of comparative neurology [J Comp Neurol] 2018 Oct 01; Vol. 526 (14), pp. 2149-2164. Date of Electronic Publication: 2018 Sep 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003-> : Hoboken, N.J. : Wiley-Liss
Original Publication: Philadelphia Wistar Institute of Anatomy and Biology
مواضيع طبية MeSH: Glucagon-Like Peptide 1/*physiology , Nerve Net/*physiology , Solitary Nucleus/*cytology , Solitary Nucleus/*physiology , Synapses/*physiology, Animals ; Female ; Glucagon-Like Peptide-1 Receptor/biosynthesis ; Glucagon-Like Peptide-1 Receptor/genetics ; Glutamate Decarboxylase ; Male ; Mice ; Mice, Transgenic ; Nerve Net/cytology ; Proglucagon/metabolism ; Prolactin-Releasing Hormone/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/physiology ; Solitary Nucleus/ultrastructure ; Synapses/ultrastructure
مستخلص: Glutamatergic neurons that express pre-proglucagon (PPG) and are immunopositive (+) for glucagon-like peptide-1 (i.e., GLP-1+ neurons) are located within the caudal nucleus of the solitary tract (cNTS) and medullary reticular formation in rats and mice. GLP-1 neurons give rise to an extensive central network in which GLP-1 receptor (GLP-1R) signaling suppresses food intake, attenuates rewarding, increases avoidance, and stimulates stress responses, partly via GLP-1R signaling within the cNTS. In mice, noradrenergic (A2) cNTS neurons express GLP-1R, whereas PPG neurons do not. In this study, confocal microscopy in rats confirmed that prolactin-releasing peptide (PrRP)+ A2 neurons are closely apposed by GLP-1+ axonal varicosities. Surprisingly, GLP-1+ appositions were also observed on dendrites of PPG/GLP-1+ neurons in both species, and electron microscopy in rats revealed that GLP-1+ boutons form asymmetric synaptic contacts with GLP-1+ dendrites. However, RNAscope confirmed that rat GLP-1 neurons do not express GLP-1R mRNA. Similarly, Ca 2+ imaging of somatic and dendritic responses in mouse ex vivo slices confirmed that PPG neurons do not respond directly to GLP-1, and a mouse crossbreeding strategy revealed that <1% of PPG neurons co-express GLP-1R. Collectively, these data suggest that GLP-1R signaling pathways modulate the activity of PrRP+ A2 neurons, and also reveal a local "feed-forward" synaptic network among GLP-1 neurons that apparently does not use GLP-1R signaling. This local GLP-1 network may instead use glutamatergic signaling to facilitate dynamic and potentially selective recruitment of GLP-1 neural populations that shape behavioral and physiological responses to internal and external challenges.
(© 2018 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals, Inc.)
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معلومات مُعتمدة: MR/N02589X/1 United Kingdom MRC_ Medical Research Council; P40 RR018604 United States RR NCRR NIH HHS; R01 DK100685 United States DK NIDDK NIH HHS; R01 MH059911 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: GABA; NTS; RRID: AB_2314562; RRID: AB_300798; RRID: AB_518978; glutamate; local circuit network; noradrenergic; preproglucagon; prolactin-releasing peptide; synapse
المشرفين على المادة: 0 (Glucagon-Like Peptide-1 Receptor)
0 (Prolactin-Releasing Hormone)
55963-74-1 (Proglucagon)
89750-14-1 (Glucagon-Like Peptide 1)
EC 4.1.1.15 (Glutamate Decarboxylase)
EC 4.1.1.15 (glutamate decarboxylase 1)
تواريخ الأحداث: Date Created: 20180719 Date Completed: 20191104 Latest Revision: 20231115
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6193818
DOI: 10.1002/cne.24482
PMID: 30019398
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9861
DOI:10.1002/cne.24482