دورية أكاديمية
An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11.
| العنوان: | An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11. |
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| المؤلفون: | Stefanelli P; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address: paola.stefanelli@iss.it., Fazio C; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Vacca P; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Palmieri A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Ambrosio L; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Neri A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Piana A; Department of Medical Surgical and Experimental Sciences, University Hospital of Sassari, Italy., Castiglia P; Department of Medical Surgical and Experimental Sciences, University Hospital of Sassari, Italy., Argiolas F; Servizio promozione della salute e osservatorio epidemiologico, Assessorato dell'Igiene e Sanità e dell'assistenza sociale-Regione Autonoma della Sardegna, Italy., Santus S; Public Health Service, Local Health Unit, Cagliari, Italy., Masala L; Laboratory SS Trinità Hospital, Sardinian Health Service, Italy., Steri G; Public Health Service, Local Health Unit, Cagliari, Italy., Riccardo F; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Iannazzo S; Director General for Health Prevention, Ministry of Health, Rome, Italy., Maraglino FP; Director General for Health Prevention, Ministry of Health, Rome, Italy., D'Amario C; Director General for Health Prevention, Ministry of Health, Rome, Italy., Rezza G; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. |
| المصدر: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2019 Jan; Vol. 25 (1), pp. 111.e1-111.e4. Date of Electronic Publication: 2018 Jul 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Elsevier Original Publication: Paris : Decker Europe, c1995- |
| مواضيع طبية MeSH: | Disease Outbreaks*, Bacterial Capsules/*immunology , Meningococcal Infections/*epidemiology , Meningococcal Infections/*microbiology , Neisseria meningitidis/*pathogenicity, Adolescent ; Anti-Bacterial Agents/therapeutic use ; Antigens, Bacterial/immunology ; Bacterial Capsules/genetics ; Female ; Humans ; Italy/epidemiology ; Male ; Meningococcal Infections/transmission ; Middle Aged ; Neisseria meningitidis/genetics ; Serogroup ; Virulence ; Whole Genome Sequencing ; Young Adult |
| مستخلص: | Objectives: The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia. Methods: Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS). Results: Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18-21 years; CFR 40%) were due to a unique strain B:P1.5-1,10-8:F3-6:ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented. Conclusions: We observed five IMD cases due to the same switched MenB strain. The hypervirulent B:P1.5-1,10-8:F3-6:ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action. (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Capsular switching; Hypervirulent; Invasive meningococcal disease; Italy; Neisseria meningitides; Outbreak; Whole-genome sequencing |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antigens, Bacterial) |
| تواريخ الأحداث: | Date Created: 20180724 Date Completed: 20190425 Latest Revision: 20190425 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.cmi.2018.07.014 |
| PMID: | 30036673 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1469-0691 |
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| DOI: | 10.1016/j.cmi.2018.07.014 |