دورية أكاديمية
Multiparametric analysis of colorectal cancer immune responses.
| العنوان: | Multiparametric analysis of colorectal cancer immune responses. |
|---|---|
| المؤلفون: | Leman JK; Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand., Sandford SK; Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand., Rhodes JL; Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand., Kemp RA; Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand. roslyn.kemp@otago.ac.nz. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2018 Jul 21; Vol. 24 (27), pp. 2995-3005. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*analysis , CD8-Positive T-Lymphocytes/*immunology , Colorectal Neoplasms/*immunology , Lymphocytes, Tumor-Infiltrating/*immunology, Biomarkers, Tumor/immunology ; Cell Separation ; Clinical Decision-Making ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Disease-Free Survival ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Mass Spectrometry/methods ; Microscopy, Confocal ; Prognosis |
| مستخلص: | Colorectal cancer (CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth - progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3 + and CD8 + T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. Competing Interests: Conflict-of-interest statement: The authors declare no conflicts of interest. |
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| فهرسة مساهمة: | Keywords: Colorectal cancer; Flow cytometry; Immune cells; Immunohistochemistry; Mass cytometry; Microscopy; Multiparametric analysis |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) |
| تواريخ الأحداث: | Date Created: 20180725 Date Completed: 20181105 Latest Revision: 20230926 |
| رمز التحديث: | 20230926 |
| مُعرف محوري في PubMed: | PMC6054948 |
| DOI: | 10.3748/wjg.v24.i27.2995 |
| PMID: | 30038466 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
|---|---|
| DOI: | 10.3748/wjg.v24.i27.2995 |