دورية أكاديمية
أعرض في EDS

Advancements in Host-Based Interventions for Influenza Treatment.

التفاصيل البيبلوغرافية
العنوان: Advancements in Host-Based Interventions for Influenza Treatment.
المؤلفون: Yip TF; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, Hong Kong., Selim ASM; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, Hong Kong., Lian I; School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore., Lee SM; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, Hong Kong.
المصدر: Frontiers in immunology [Front Immunol] 2018 Jul 10; Vol. 9, pp. 1547. Date of Electronic Publication: 2018 Jul 10 (Print Publication: 2018).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: Influenza is a major acute respiratory infection that causes mortality and morbidity worldwide. Two classes of conventional antivirals, M2 ion channel blockers and neuraminidase inhibitors, are mainstays in managing influenza disease to lessen symptoms while minimizing hospitalization and death in patients with severe influenza. However, the development of viral resistance to both drug classes has become a major public health concern. Vaccines are prophylaxis mainstays but are limited in efficacy due to the difficulty in matching predicted dominant viral strains to circulating strains. As such, other potential interventions are being explored. Since viruses rely on host cellular functions to replicate, recent therapeutic developments focus on targeting host factors involved in virus replication. Besides controlling virus replication, potential targets for drug development include controlling virus-induced host immune responses such as the recently suggested involvement of innate lymphoid cells and NADPH oxidases in influenza virus pathogenesis and immune cell metabolism. In this review, we will discuss the advancements in novel host-based interventions for treating influenza disease.
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فهرسة مساهمة: Keywords: cytokines; host factors; immunomodulation; influenza; metabolism
تواريخ الأحداث: Date Created: 20180726 Latest Revision: 20191120
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6048202
DOI: 10.3389/fimmu.2018.01547
PMID: 30042762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2018.01547