دورية أكاديمية
Induction of oxidative stress in human aqueous and vitreous humors by Nd:YAG laser posterior capsulotomy.
| العنوان: | Induction of oxidative stress in human aqueous and vitreous humors by Nd:YAG laser posterior capsulotomy. |
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| المؤلفون: | Bergandi L; Department of Oncology, University of Torino, Torino 10126, Italy., Skorokhod OA; Department of Oncology, University of Torino, Torino 10126, Italy.; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm SE-106 91, Sweden., Franzone F; Eye Clinic Section and Specialization School in Ophthalmology, Department of Surgical Sciences, University of Torino, Torino 10126, Italy., La Grotta R; Department of Oncology, University of Torino, Torino 10126, Italy., Schwarzer E; Department of Oncology, University of Torino, Torino 10126, Italy., Nuzzi R; Eye Clinic Section and Specialization School in Ophthalmology, Department of Surgical Sciences, University of Torino, Torino 10126, Italy. |
| المصدر: | International journal of ophthalmology [Int J Ophthalmol] 2018 Jul 18; Vol. 11 (7), pp. 1145-1151. Date of Electronic Publication: 2018 Jul 18 (Print Publication: 2018). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Press of International Journal of Ophthalmology Country of Publication: China NLM ID: 101553860 Publication Model: eCollection Cited Medium: Print ISSN: 2222-3959 (Print) Linking ISSN: 22223959 NLM ISO Abbreviation: Int J Ophthalmol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Xi'an, China : Press of International Journal of Ophthalmology |
| مستخلص: | Aim: To evaluate whether the Q-switched Nd:YAG laser treatment applied in routine capsulotomy elicits oxidative stress in aqueous and vitreous humors. Methods: Thirty-six patients who had to undergo a 25 gauge pars plana vitrectomy due to vitreoretinal disorders were enrolled, 15 of them underwent a Q-switched Nd:YAG laser capsulotomy 7d before vitrectomy due to posterior capsule opacification (PCO) (Nd:YAG laser group) while the remaining 21 patients were not laser treated before vitrectomy (no Nd:YAG laser group). Samples of the aqueous and vitreous humors were collected during vitrectomy from all patients for the assessment of oxidative parameters which were compared between the Nd:YAG laser group and no Nd:YAG laser group. Thiobarbituric acid reactive substances (TBARS), a product of membrane lipid peroxidation, nitrite levels, the antioxidative activities of SOD and catalase, the 4-HNE-protein conjugate formation, indicating structural modifications in proteins due to lipoperoxidation, were assessed in aqueous and vitreous samples. Results: In the human vitreous humor TBARS levels are significantly higher in the Nd:YAG laser group compared to the no Nd:YAG laser group and importantly, there is a significant correlation between the TBARS levels and the total energy of Nd:YAG laser used during capsulotomy. Moreover the anti-oxidative activities of SOD and catalase were significantly decreased by Nd:YAG laser treatment, both in aqueous and vitreous humors. In accordance with the TBARS data and anti-oxidative enzyme activities, significantly higher levels of proteins were conjugated with the lipoperoxidation product 4-HNE in the aqueous and vitreous humors in the Nd:YAG laser-treated group in comparison to no Nd:YAG laser group. Conclusion: These data, clearly suggest that any change that Q-switched Nd:YAG photo disruption may cause in the aqueous and vitreous compartments, resulting in a higher level of oxidative damage might be of considerable clinical significance particularly by accelerating the aging of the anterior and posterior segments of the eye and by worsening the intraocular pressure, the uveal, the retinal (especially macular) pathologies. |
| References: | Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1041-6. (PMID: 15037566) Turk J Ophthalmol. 2016 Oct;46(5):205-208. (PMID: 28058161) Free Radic Biol Med. 2014 Oct;75:210-21. (PMID: 25017964) Klin Monbl Augenheilkd. 1994 May;204(5):286-7. (PMID: 8051851) Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3469-79. (PMID: 17652714) Free Radic Biol Med. 2015 Dec;89:624-37. (PMID: 26459031) J Signal Transduct. 2012;2012:646354. (PMID: 21977319) Oxid Med Cell Longev. 2015;2015:638416. (PMID: 25969702) Ophthalmology. 1997 Aug;104(8):1287-93. (PMID: 9261315) Reprod Biol Endocrinol. 2017 Jun 23;15(1):47. (PMID: 28645283) Lancet Glob Health. 2017 Dec;5(12):e1221-e1234. (PMID: 29032195) Optom Clin. 1995;4(4):69-83. (PMID: 7488799) BMC Med Genet. 2008 Jul 07;9:62. (PMID: 18606005) Chem Res Toxicol. 2009 Mar 16;22(3):433-45. (PMID: 19191707) Ophthalmology. 2002 Oct;109(10):1807-12; discussion 1813. (PMID: 12359598) Acta Biochim Pol. 2010;57(2):165-71. (PMID: 20559572) Cochrane Database Syst Rev. 2017 Sep 20;9:CD010510. (PMID: 28931202) J Clin Invest. 1998 Aug 1;102(3):595-605. (PMID: 9691096) Med Res Rev. 2008 Jul;28(4):569-631. (PMID: 18058921) Free Radic Res Commun. 1988;5(2):55-66. (PMID: 3063619) Med Hypothesis Discov Innov Ophthalmol. 2014 Summer;3(2):45-50. (PMID: 25738159) Int Ophthalmol. 1981 May;3(3):129-39. (PMID: 7196390) J Am Intraocul Implant Soc. 1980 Oct;6(4):352-4. (PMID: 7440377) J Cataract Refract Surg. 2011 Jan;37(1):173-93. (PMID: 21183112) Mol Vis. 2015 Sep 20;21:1106-12. (PMID: 26396488) |
| فهرسة مساهمة: | Keywords: Q-switched Nd:YAG laser; oxidative stress; posterior capsule opacification; vitrectomy |
| تواريخ الأحداث: | Date Created: 20180727 Latest Revision: 20201001 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6048321 |
| DOI: | 10.18240/ijo.2018.07.12 |
| PMID: | 30046531 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2222-3959 |
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| DOI: | 10.18240/ijo.2018.07.12 |