دورية أكاديمية
أعرض في EDS

Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin.

التفاصيل البيبلوغرافية
العنوان: Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin.
المؤلفون: Barretto KT; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America., Swanson CM; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America., Nguyen CL; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America., Annis DS; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America., Esnault SJ; Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America., Mosher DF; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America., Johansson MW; Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America.
المصدر: PloS one [PLoS One] 2018 Jul 26; Vol. 13 (7), pp. e0201320. Date of Electronic Publication: 2018 Jul 26 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cell Adhesion Molecules/*immunology , Eosinophils/*cytology , Extracellular Matrix Proteins/*immunology , Transforming Growth Factor beta/*immunology, Cell Adhesion ; Cell Migration Assays, Leukocyte ; Cell Movement ; Eosinophils/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Humans ; Interleukin-3/immunology ; Interleukin-5/immunology
مستخلص: Periostin, which is induced by interleukin (IL)-13, is an extracellular matrix (ECM) protein that supports αMβ2 integrin-mediated adhesion and migration of IL-5-stimulated eosinophils. Transforming growth factor (TGF)-β-induced protein (TGFBI) is a widely expressed periostin paralog known to support monocyte adhesion. Our objective was to compare eosinophil adhesion and migration on TGFBI and periostin in the presence of IL-5-family cytokines. Eosinophil adhesion after 1 h and random motility over 20 h in the presence of various concentrations of IL-5, IL-3, or granulocyte macrophage-colony stimulating factor (GM-CSF) were quantified in wells coated with various concentrations of TGFBI or periostin. Results were compared to video microscopy of eosinophils. Cytokine-stimulated eosinophils adhered equivalently well to TGFBI or periostin in a coating concentration-dependent manner. Adhesion was blocked by anti-αMβ2 and stimulated at the lowest concentration by GM-CSF. In the motility assay, periostin was more potent than TGFBI, the coating-concentration effect was bimodal, and IL-3 was the most potent cytokine. Video microscopy revealed that under the optimal coating condition of 5 μg/ml periostin, most eosinophils migrated persistently and were polarized and acorn-shaped with a ruffling forward edge and granules gathered together, in front of the nucleus. On 10 μg/ml periostin or TGFBI, more eosinophils adopted a flattened pancake morphology with dispersed granules and nuclear lobes, and slower migration. Conversion between acorn and pancake morphologies were observed. We conclude that TGFBI or periostin supports two modes of migration by IL-5 family cytokine-activated eosinophils. The rapid mode is favored by intermediate protein coatings and the slower by higher coating concentrations. We speculate that eosinophils move by haptotaxis up a gradient of adhesive ECM protein and then slow down to surveil the tissue.
Competing Interests: We have read the journal's policy and the authors of this manuscript have the following competing interests: MWJ received a fee from Genentech for speaking and funds for research from Hoffmann-La Roche, and was an advisory board member for Genentech. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.
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معلومات مُعتمدة: P01 HL088594 United States HL NHLBI NIH HHS; R01 AI125390 United States AI NIAID NIH HHS; UL1 RR025011 United States RR NCRR NIH HHS
المشرفين على المادة: 0 (Cell Adhesion Molecules)
0 (Extracellular Matrix Proteins)
0 (Interleukin-3)
0 (Interleukin-5)
0 (POSTN protein, human)
0 (Transforming Growth Factor beta)
148710-76-3 (betaIG-H3 protein)
83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
تواريخ الأحداث: Date Created: 20180727 Date Completed: 20190117 Latest Revision: 20240216
رمز التحديث: 20240216
مُعرف محوري في PubMed: PMC6062114
DOI: 10.1371/journal.pone.0201320
PMID: 30048528
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0201320