دورية أكاديمية
Approaches used to estimate bioavailability when deriving dietary reference values for iron and zinc in adults.
| العنوان: | Approaches used to estimate bioavailability when deriving dietary reference values for iron and zinc in adults. |
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| المؤلفون: | Fairweather-Tait SJ; Norwich Medical School,Bob Champion Research and Educational Building,University of East Anglia,James Watson Road,Norwich NR4 7UQ,UK., de Sesmaisons A; Nutrition Unit,European Food Safety Authority,Parma,Italy. |
| المصدر: | The Proceedings of the Nutrition Society [Proc Nutr Soc] 2018 Jul 27, pp. 1-7. Date of Electronic Publication: 2018 Jul 27. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 7505881 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2719 (Electronic) Linking ISSN: 00296651 NLM ISO Abbreviation: Proc Nutr Soc |
| أسماء مطبوعة: | Publication: <1999->: [Wallingford, Oxon, UK] : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: London, Cambridge Univ. Press [etc.] |
| مستخلص: | This review aims to describe approaches used to estimate bioavailability when deriving dietary reference values (DRV) for iron and zinc using the factorial approach. Various values have been applied by different expert bodies to convert absorbed iron or zinc into dietary intakes, and these are summarised in this review. The European Food Safety Authority (EFSA) derived zinc requirements from a trivariate saturation response model describing the relationship between zinc absorption and dietary zinc and phytate. The average requirement for men and women was determined as the intercept of the total absorbed zinc needed to meet physiological requirements, calculated according to body weight, with phytate intake levels of 300, 600, 900 and 1200 mg/d, which are representative of mean/median intakes observed in European populations. For iron, the method employed by EFSA was to use whole body iron losses, determined from radioisotope dilution studies, to calculate the quantity of absorbed iron required to maintain null balance. Absorption from the diet was estimated from a probability model based on measures of iron intake and status and physiological requirements for absorbed iron. Average dietary requirements were derived for men and pre- and post-menopausal women. Taking into consideration the complexity of deriving DRV for iron and zinc, mainly due to the limited knowledge on dietary bioavailability, it appears that EFSA has made maximum use of the most relevant up-to-date data to develop novel and transparent DRV for these nutrients. |
| فهرسة مساهمة: | Keywords: AI adequate intake; AR average requirement; DRV dietary reference values; EFSA The European Food Safety Agency; Bioavailability; Dietary reference values; Iron; Zinc |
| تواريخ الأحداث: | Date Created: 20180728 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| DOI: | 10.1017/S0029665118000484 |
| PMID: | 30049292 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2719 |
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| DOI: | 10.1017/S0029665118000484 |