دورية أكاديمية
Heterogeneity of Duodenal Neuroendocrine Tumors: An Italian Multi-center Experience.
| العنوان: | Heterogeneity of Duodenal Neuroendocrine Tumors: An Italian Multi-center Experience. |
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| المؤلفون: | Massironi S; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. sara.massironi@policlinico.mi.it., Campana D; Department of Medical and Surgical Sciences, Bologna University St. Orsola-Malpighi Polyclinic Hospital, Bologna, Italy., Partelli S; Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, 'Vita-Salute' University, Milan, Italy., Panzuto F; Digestive and Liver Diseases Department, University 'La Sapienza' of Rome Sant'Andrea Hospital, Rome, Italy., Rossi RE; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy., Faggiano A; Division of Endocrinology, Department of Clinical Medicine and Surgery, University 'Federico II' of Naples, Naples, Italy., Brighi N; Department of Medical and Surgical Sciences, Bologna University St. Orsola-Malpighi Polyclinic Hospital, Bologna, Italy., Falconi M; Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, 'Vita-Salute' University, Milan, Italy., Rinzivillo M; Digestive and Liver Diseases Department, University 'La Sapienza' of Rome Sant'Andrea Hospital, Rome, Italy., Delle Fave G; Digestive and Liver Diseases Department, University 'La Sapienza' of Rome Sant'Andrea Hospital, Rome, Italy., Colao AM; Division of Endocrinology, Department of Clinical Medicine and Surgery, University 'Federico II' of Naples, Naples, Italy., Conte D; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. |
| المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2018 Oct; Vol. 25 (11), pp. 3200-3206. Date of Electronic Publication: 2018 Jul 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Duodenal Neoplasms/*pathology , Liver Neoplasms/*secondary , Neuroendocrine Tumors/*pathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Duodenal Neoplasms/mortality ; Duodenal Neoplasms/therapy ; Female ; Follow-Up Studies ; Humans ; Italy ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Lymphatic Metastasis ; Male ; Middle Aged ; Neuroendocrine Tumors/mortality ; Neuroendocrine Tumors/therapy ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult |
| مستخلص: | Background: The optimal management of duodenal neuroendocrine neoplasms (dNENs) is unclear, and endoscopic resection is increasingly performed instead of surgery. Methods: This is a retrospective analysis of patients with histologically confirmed diagnosis of dNENs, managed at five Italian tertiary referral Centers in Italy. Results: From 2000 to 2017, 108 patients (69 males, 39 females, median age 59.5 years) were included in this study. Seventy-one patients had G1, 21 G2, 4 G3 dNENs (12 Ki-67 not available). Fifty-four patients showed metastases at diagnosis, and 20 patients developed metachronous metastases. Thirty patients had a functioning dNEN (14 metastatic). Fifty-seven patients had the dNEN surgically resected, 16 endoscopically, 23 metastatic, received medical therapy + surgery or endoscopy. Seven patients underwent liver-directed therapies, and one patient had PRRT. Median OS was 187 months. During a median follow-up of 76 months, 20 patients died (19 of disease-related causes). At Cox's multivariate proportional hazard regression, grading and age were the only variables independently related to OS. Median PFS was 170 months. Grading and staging at the initial diagnosis were independently related to PFS. No differences in terms of OS and PFS were observed between patients treated surgically or endoscopically. Conclusions: dNENs prognosis may be highly variable. These tumors can be metastatic in up to 50% of cases at the time of first diagnosis and can develop metastases thereafter. Functioning neoplasms express high metastatic potential. Nuclear imaging should be performed to exclude distant metastases in all dNENs. Endoscopy and surgery play a primary role in the management of the disease. Further prospective studies are needed. |
| التعليقات: | Comment in: Ann Surg Oncol. 2018 Dec;25(Suppl 3):858-859. (PMID: 30145647) |
| تواريخ الأحداث: | Date Created: 20180729 Date Completed: 20190118 Latest Revision: 20190118 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1245/s10434-018-6673-5 |
| PMID: | 30054824 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1534-4681 |
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| DOI: | 10.1245/s10434-018-6673-5 |