دورية أكاديمية
Gastrointestinal Manifestations of Systemic Sclerosis.
| العنوان: | Gastrointestinal Manifestations of Systemic Sclerosis. |
|---|---|
| المؤلفون: | McFarlane IM; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Bhamra MS; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Kreps A; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Iqbal S; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Al-Ani F; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Saladini-Aponte C; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Grant C; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Singh S; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Awwal K; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Koci K; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Saperstein Y; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Arroyo-Mercado FM; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Laskar DB; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA., Atluri P; Division of Rheumatology and Gastroenterology, Department of Medicine and Pathology, Hospitals Kings County Hospital Brooklyn, State University of New York, USA. |
| المصدر: | Rheumatology (Sunnyvale, Calif.) [Rheumatology (Sunnyvale)] 2018; Vol. 8 (1). Date of Electronic Publication: 2018 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: OMICS Pub. Group Country of Publication: United States NLM ID: 101580636 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2161-1149 (Print) NLM ISO Abbreviation: Rheumatology (Sunnyvale) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Sunnyvale, Calif. : OMICS Pub. Group |
| مستخلص: | Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative alterations of the microvasculature leading to fibrosis and loss of function of the skin and internal organs. Gastrointestinal manifestations of SSc are the most commonly encountered complications of the disease affecting nearly 90% of the SSc population. Among these complications, the esophagus and the anorectum are the most commonly affected. However, this devastating disorder does not spare any part of the gastrointestinal tract (GIT), and includes the oral cavity, esophagus, stomach, small and large bowels as well as the liver and pancreas. In this review, we present the current understanding of the pathophysiologic mechanisms of SSc including vasculopathy, endothelial to mesenchymal transformation as well as the autoimmune pathogenetic pathways. We also discuss the clinical presentation and diagnosis of each part of the GIT affected by SSc. Finally, we highlight the latest developments in the management of this disease, addressing the severe malnutrition that affects this vulnerable patient population and ways to assess and improve the nutritional status of the patients. |
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| معلومات مُعتمدة: | P20 MD006875 United States MD NIMHD NIH HHS |
| فهرسة مساهمة: | Keywords: Diagnosis; Esophagus; Gastrointestinal; Interstitial lung disease; Management; Pathogenesis; Scleroderma; Systemic sclerosis |
| تواريخ الأحداث: | Date Created: 20180731 Latest Revision: 20201001 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6059963 |
| DOI: | 10.4172/2161-1149.1000235 |
| PMID: | 30057856 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2161-1149 |
|---|---|
| DOI: | 10.4172/2161-1149.1000235 |