دورية أكاديمية
Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations.
| العنوان: | Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations. |
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| المؤلفون: | Elion DL; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: Rebecca.cook@vanderbilt.edu. |
| المصدر: | Trends in molecular medicine [Trends Mol Med] 2018 Aug; Vol. 24 (8), pp. 655-656. Date of Electronic Publication: 2018 Jun 28. |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-499X (Electronic) Linking ISSN: 14714914 NLM ISO Abbreviation: Trends Mol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science Ltd., c2001- |
| مواضيع طبية MeSH: | Triple Negative Breast Neoplasms*, Antineoplastic Combined Chemotherapy Protocols ; Drug Resistance, Neoplasm ; Humans ; Neoadjuvant Therapy |
| مستخلص: | Chemotherapy is the most commonly prescribed treatment for patients with aggressive and lethal triple negative breast cancers (TNBCs), which often develop chemoresistance. A recent study combined single nucleus sequencing, single cell RNA sequencing, and evolutionary biology to understand how tumor cells use genetic and phenotypic diversity to evade the selective pressures of neoadjuvant chemotherapy. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| التعليقات: | Comment on: Cell. 2018 May 3;173(4):879-893.e13. (PMID: 29681456) |
| فهرسة مساهمة: | Keywords: chemotherapy; clonal tumor cell subpopulations; intratumoral heterogeneity; pathological complete response; transcriptional reprogramming; triple negative breast cancer |
| تواريخ الأحداث: | Date Created: 20180801 Date Completed: 20190307 Latest Revision: 20191218 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.molmed.2018.06.003 |
| PMID: | 30060834 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1471-499X |
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| DOI: | 10.1016/j.molmed.2018.06.003 |