دورية أكاديمية
أعرض في EDS

Long-term high-protein diet intake reverts weight gain and attenuates metabolic dysfunction on high-sucrose-fed adult rats.

التفاصيل البيبلوغرافية
العنوان: Long-term high-protein diet intake reverts weight gain and attenuates metabolic dysfunction on high-sucrose-fed adult rats.
المؤلفون: Sousa RML; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., Ribeiro NLX; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., Pinto BAS; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., Sanches JR; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., da Silva MU; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil., Coêlho CFF; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., França LM; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., de Figueiredo Neto JA; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil.; 3Department of Medicine I, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil., Paes AMA; 1Laboratory of Experimental Physiology, Department of Physiological Sciences - DCF, Health and Biological Sciences Centre, Federal University of Maranhão - UFMA, Avenida dos Portugueses, 1966. Cidade Universitária D. Delgado, São Luís, MA 65080-805 Brazil.; 2Health Sciences Graduate Program, Health and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA Brazil.
المصدر: Nutrition & metabolism [Nutr Metab (Lond)] 2018 Jul 24; Vol. 15, pp. 53. Date of Electronic Publication: 2018 Jul 24 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101231644 Publication Model: eCollection Cited Medium: Print ISSN: 1743-7075 (Print) Linking ISSN: 17437075 NLM ISO Abbreviation: Nutr Metab (Lond) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2004-
مستخلص: Background: Consumption of added sugars has been considered a worldwide public health concern by its association with metabolic syndrome and its comorbidities. Meanwhile, current studies have suggested high-protein diets to promote weight loss and improved metabolic outcomes. Thus, this study aimed to investigate the effects of long-term high-protein diet (HPD, 34.3% protein) intake on high-sucrose-fed rats.
Methods: Weaned male Wistar rats were randomized into two groups: rats fed a standard chow (CT/CT, 10% sucrose) or rats fed a high-sucrose diet (HSD, 25% sucrose) for a 20-week observational period. Subsequently, HS/HS animals were randomized into 3 new groups: rats maintained on HSD diet (HS/HS); rats submitted to HSD replacement by standard chow (HS/CT); and those with HSD replaced by HPD (HS/HP). All groups were followed up for 12 weeks during which we investigated the effects of HPD on body weight, energy intake, obesity development, glicemic/lipid profile, glucose tolerance, insulin resistance, tissue weight (adipose tissue, liver and skeletal muscles), lipolytic activity, liver lipoperoxidation and histology, as well as serum markers of hepatic function.
Results: Post-weaning exposure to HSD led to metabolic syndrome phenotype at adulthood, herein characterized by central obesity, glucose intolerance, dyslipidaemia and insulin resistance. Only HPD feeding was able to revert weight gain and adipose tissue accumulation, as well as restore adipose tissue lipolytic response to sympathetic stimulus. On the other hand, either HPD or withdrawal from HSD promoted very similar metabolic outcomes upon 12-week nutritional intervention. HS/HP and HS/CT rats showed reduced fasting serum levels of glucose, triacylglycerol and total cholesterol, which were correlated with the improvement of peripheral insulin sensitivity, as inferred from k ITT and TyG Index values. Both nutritional interventions restored liver morphofunctional patterns, but only HPD restored lipid peroxidation.
Conclusions: Our data showed that 12-week intake of an isocaloric moderately high-protein diet consistently restored high-sucrose-induced central adiposity and obesity in addition to the attenuation of other important metabolic outcomes, such as improvement of glucolipid homeostasis associated to increased insulin sensitivity and reversal of hepatic steatosis. On the other hand, simple withdrawal from high-sucrose consumption also promoted the abovementioned metabolic outcomes with no impact on body weight.
Competing Interests: All procedures were performed in accordance with the rules of Brazilian Council for the Control of Animal Experimentation (CONCEA) and approved by the Ethical Committee on Animal Use and Welfare (CEUA) of CEUMA University under the protocol number 177/17.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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فهرسة مساهمة: Keywords: High-protein diet; High-sucrose diet; Metabolic syndrome; Withdrawal of sucrose
تواريخ الأحداث: Date Created: 20180801 Latest Revision: 20220318
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6057058
DOI: 10.1186/s12986-018-0290-y
PMID: 30061916
قاعدة البيانات: MEDLINE
الوصف
تدمد:1743-7075
DOI:10.1186/s12986-018-0290-y