دورية أكاديمية
Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.
العنوان: | Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification. |
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المؤلفون: | Yu B; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Hafiane A; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Thanassoulis G; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Ott L; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Filwood N; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Cerruti M; Department of Materials Engineering, McGill University, Montreal, Quebec, Canada., Gourgas O; Department of Materials Engineering, McGill University, Montreal, Quebec, Canada., Shum-Tim D; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Al Kindi H; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., de Varennes B; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Alsheikh-Ali A; College of Medicine, Mohammed Bin Rashid University of Medical and Health Sciences, Dubai, United Arab Emirates., Genest J; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Schwertani A; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada. |
المصدر: | JACC. Basic to translational science [JACC Basic Transl Sci] 2017 Aug 28; Vol. 2 (4), pp. 358-371. Date of Electronic Publication: 2017 Aug 28 (Print Publication: 2017). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]- |
مستخلص: | Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased SOX9 and matrix Gla protein (p < 0.001). Inhibition of MAPK38 and GSK3β significantly reduced Lp(a)-induced calcification of human aortic valve interstitial cells (p < 0.001). There was abundant presence of Lp(a) and E06 immunoreactivity in diseased human aortic valves. The present study demonstrates a causal effect for Lp(a) in aortic valve calcification and suggests that interfering with the Lp(a)pathway could provide a novel therapeutic approach in the management of this debilitating disease. |
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فهرسة مساهمة: | Keywords: ALP, alkaline phosphatase; BMP, bone morphogenetic protein; FWHM, full width half maximum; HAVIC, human aortic valve interstitial cell; LDL, low-density lipoprotein; LOX-1, oxidized LDL receptor 1; Lp(a), lipoprotein(a); MAPK, mitogen-activated protein kinase; MGP, matrix Gla protein; OxPL, oxidized phospholipid; Raman spectroscopy; apo(a), apolipoprotein(a); mRNA, messenger ribonucleic acid; oxidized phospholipids; real-time PCR; stenosis |
تواريخ الأحداث: | Date Created: 20180801 Latest Revision: 20201001 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6034440 |
DOI: | 10.1016/j.jacbts.2017.03.015 |
PMID: | 30062157 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2452-302X |
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DOI: | 10.1016/j.jacbts.2017.03.015 |