دورية أكاديمية
أعرض في EDS

Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.

التفاصيل البيبلوغرافية
العنوان: Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.
المؤلفون: Yu B; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Hafiane A; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Thanassoulis G; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Ott L; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Filwood N; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Cerruti M; Department of Materials Engineering, McGill University, Montreal, Quebec, Canada., Gourgas O; Department of Materials Engineering, McGill University, Montreal, Quebec, Canada., Shum-Tim D; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Al Kindi H; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., de Varennes B; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Alsheikh-Ali A; College of Medicine, Mohammed Bin Rashid University of Medical and Health Sciences, Dubai, United Arab Emirates., Genest J; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada., Schwertani A; Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2017 Aug 28; Vol. 2 (4), pp. 358-371. Date of Electronic Publication: 2017 Aug 28 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased SOX9 and matrix Gla protein (p < 0.001). Inhibition of MAPK38 and GSK3β significantly reduced Lp(a)-induced calcification of human aortic valve interstitial cells (p < 0.001). There was abundant presence of Lp(a) and E06 immunoreactivity in diseased human aortic valves. The present study demonstrates a causal effect for Lp(a) in aortic valve calcification and suggests that interfering with the Lp(a)pathway could provide a novel therapeutic approach in the management of this debilitating disease.
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فهرسة مساهمة: Keywords: ALP, alkaline phosphatase; BMP, bone morphogenetic protein; FWHM, full width half maximum; HAVIC, human aortic valve interstitial cell; LDL, low-density lipoprotein; LOX-1, oxidized LDL receptor 1; Lp(a), lipoprotein(a); MAPK, mitogen-activated protein kinase; MGP, matrix Gla protein; OxPL, oxidized phospholipid; Raman spectroscopy; apo(a), apolipoprotein(a); mRNA, messenger ribonucleic acid; oxidized phospholipids; real-time PCR; stenosis
تواريخ الأحداث: Date Created: 20180801 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6034440
DOI: 10.1016/j.jacbts.2017.03.015
PMID: 30062157
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2017.03.015