دورية أكاديمية
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Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model.

التفاصيل البيبلوغرافية
العنوان: Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model.
المؤلفون: Garcia Ribeiro RS; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Gysemans C; Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., da Cunha JPMCM; Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Manshian BB; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Jirak D; MR Spectroscopy Unit, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 140 21, Prague, Czech Republic.; Department of Biophysics, Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovska 1, 120 00, Prague 2, Czech Republic., Kriz J; Diabetes Center, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 140 21, Prague, Czech Republic., Gallo J; Diagnostic Tools & Methods/Advanced (magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Bañobre-López M; Diagnostic Tools & Methods/Advanced (magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Struys T; Lab of Histology, Biomedical Research Institute, Hasselt University, Campus Diepenbeek, Agoralaan, B3590, Diepenbeek, Belgium., De Cuyper M; Laboratory of BioNanoColloids, Interdisciplinary Research Centre, KULAK/KU LEUVEN, Etienne Sabbelaan 53, 8500, Kortrijk, Belgium., Mathieu C; Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Soenen SJ; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Gsell W; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium., Himmelreich U; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, KU LEUVEN, Herestraat 49, 3000, Leuven, Belgium. Uwe.Himmelreich@kuleuven.be.
المصدر: Scientific reports [Sci Rep] 2018 Jul 31; Vol. 8 (1), pp. 11487. Date of Electronic Publication: 2018 Jul 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Contrast Media/*metabolism , Diabetes Mellitus, Experimental/*metabolism , Diabetes Mellitus, Experimental/*pathology , Islets of Langerhans/*metabolism , Islets of Langerhans/*pathology , Magnetite Nanoparticles/*administration & dosage, Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/chemically induced ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Insulin/metabolism ; Islets of Langerhans Transplantation/methods ; Liver/metabolism ; Liver/pathology ; Longitudinal Studies ; Magnetic Resonance Imaging/methods ; Portal Vein/metabolism ; Portal Vein/pathology ; Rats ; Rats, Inbred Lew ; Rats, Wistar ; Streptozocin/pharmacology
مستخلص: Magnetoliposomes (MLs) were synthesized and tested for longitudinal monitoring of transplanted pancreatic islets using magnetic resonance imaging (MRI) in rat models. The rat insulinoma cell line INS-1E and isolated pancreatic islets from outbred and inbred rats were used to optimize labeling conditions in vitro. Strong MRI contrast was generated by islets exposed to 50 µg Fe/ml for 24 hours without any increased cell death, loss of function or other signs of toxicity. In vivo experiments showed that pancreatic islets (50-1000 units) labeled with MLs were detectable for up to 6 weeks post-transplantation in the kidney subcapsular space. Islets were also monitored for two weeks following transplantation through the portal vein of the liver. Hereby, islets labeled with MLs and transplanted under the left kidney capsule were able to correct hyperglycemia and had stable MRI signals until nephrectomy. Interestingly, in vivo MRI of streptozotocin induced diabetic rats transplanted with allogeneic islets demonstrated loss of MRI contrast between 7-16 days, indicative of loss of islet structure. MLs used in this study were not only beneficial for monitoring the location of transplanted islets in vivo with high sensitivity but also reported on islet integrity and hereby indirectly on islet function and rejection.
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معلومات مُعتمدة: EU-FP7/207-2013/289932 International EC | Seventh Framework Programme (European Union Seventh Framework Programme); IN00023001 International Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic); 686009 International EC | Horizon 2020 (European Union Framework Programme for Research and Innovation); SBO-IWT-1490061 International Agentschap voor Innovatie door Wetenschap en Technologie (Agency for Innovation by Science and Technology, Flanders)
المشرفين على المادة: 0 (Contrast Media)
0 (Insulin)
0 (Magnetite Nanoparticles)
5W494URQ81 (Streptozocin)
تواريخ الأحداث: Date Created: 20180802 Date Completed: 20191016 Latest Revision: 20240329
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC6068133
DOI: 10.1038/s41598-018-29136-9
PMID: 30065302
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-29136-9