دورية أكاديمية
Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice.
| العنوان: | Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice. |
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| المؤلفون: | Medeiros-Fonseca B; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal. pamo@utad.pt., Mestre VF, Colaço B, Pires MJ, Martins T, Gil da Costa RM, Neuparth MJ, Medeiros R, Moutinho MSS, Dias MI, Barros L, Bastos MMSM, Félix L, Venâncio C, Ferreira ICFR, Antunes LM, Oliveira PA |
| المصدر: | Food & function [Food Funct] 2018 Aug 15; Vol. 9 (8), pp. 4419-4428. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*toxicity , Human papillomavirus 16/*physiology , Laurus/*chemistry , Papillomavirus Infections/*virology , Plant Extracts/*toxicity , Uterine Cervical Neoplasms/*virology, Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Female ; Human papillomavirus 16/genetics ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice ; Mice, Transgenic ; Oxidative Stress/drug effects ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/pathology ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology |
| مستخلص: | Cancers induced by human papillomavirus (HPV) infection remain a significant public health threat, fueling the study of new therapies. Laurel (Laurus nobilis) compounds and extracts recently showed in vitro activity against HPV-transformed cell lines. This work aims to evaluate the in vivo efficacy and hepatic toxicity of a laurel extract in a transgenic mouse model of HPV16-induced cancer. The extract was administered in drinking water (20 mg per animal per day) for three consecutive weeks, using four experimental groups (n = 10) (group I: HPV16-/- without treatment, group II: treated HPV16-/-, group III: HPV16+/- without treatment and group IV: treated HPV16+/-). Following the treatment period, animals were sacrificed and skin samples were used to classify skin lesions histologically. Toxicological parameters included hematological and biochemical blood markers, splenic and hepatic histology and hepatic oxidative stress. The extract did not prevent the progression of HPV16-induced cutaneous lesions in this model. The treated wild-type animals showed mild hepatitis, while transgenic animals suffered weight loss. However, there were no changes concerning hematological, biochemical and hepatic oxidative stress markers. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20180802 Date Completed: 20181218 Latest Revision: 20181218 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1039/c8fo00783g |
| PMID: | 30066000 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
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| DOI: | 10.1039/c8fo00783g |