دورية أكاديمية
Biomarkers and renal arterial resistive index in dogs naturally infected with Leishmania infantum.
العنوان: | Biomarkers and renal arterial resistive index in dogs naturally infected with Leishmania infantum. |
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المؤلفون: | de Oliveira Frazilio F; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil. fabiano.frazilio@ufms.br., de Almeida Borges F; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., de Souza AI; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., Palumbo MIP; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., do Nascimento Ramos CA; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., Freire DH; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., Galvão ALB; Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, 15093-450, Brazil., de Freitas MG; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil., Barbosa FB; Faculty of Veterinary Medicine and Zootechnics, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, 79070-900, Brazil. |
المصدر: | Parasitology research [Parasitol Res] 2018 Nov; Vol. 117 (11), pp. 3399-3405. Date of Electronic Publication: 2018 Aug 01. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
مواضيع طبية MeSH: | Creatinine/*urine , Cystatin C/*blood , Dog Diseases/*diagnosis , Glomerulonephritis/*diagnosis , Kidney Diseases/*veterinary , Leishmaniasis, Visceral/*pathology , Nephritis, Interstitial/*diagnosis , Renal Artery/*pathology , gamma-Glutamyltransferase/*urine, Animals ; Biomarkers/urine ; Creatinine/blood ; Disease Progression ; Dog Diseases/parasitology ; Dogs ; Female ; Glomerulonephritis/parasitology ; Glomerulonephritis/veterinary ; Kidney/parasitology ; Kidney Diseases/diagnosis ; Kidney Diseases/parasitology ; Kidney Function Tests ; Leishmania infantum/isolation & purification ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/veterinary ; Male ; Nephritis, Interstitial/parasitology ; Nephritis, Interstitial/veterinary ; Serum |
مستخلص: | Canine visceral leishmaniasis frequently causes glomerulonephritis and tubulointerstitial nephritis, nephropathies for which diagnosis has been limited by the low sensitivity of traditional tests. The aim of this study was to evaluate serum cystatin C and urinary gamma-glutamyltransferase (uGGT) levels and the urinary GGT/urinary creatinine ratio (uGGT/uCR) and to measure the renal arterial resistive index (RARI) in dogs with leishmaniasis with varying degrees of renal injury based on the urine protein: creatinine ratio (UP/C) and serum creatinine (SCr) level. We tested 59 untreated adult dogs of both sexes and undefined breeds naturally infected with Leishmania infantum. The dogs were grouped into four groups based on UP/C and SCr level: group 1 (n = 15), dogs with SCr levels < 1.4 mg/dL and UP/C < 0.5; group 2 (n = 13), dogs with SCr levels < 1.4 mg/dL and UP/C of 0.5-1.0; group 3 (n = 16), dogs with SCr levels < 1.4 and UP/C > 1.0; and group 4 (n = 15), dogs with SCr levels > 1.4. A fifth group of healthy dogs (n = 10) was the control. uGGT concentrations and uGGT/uCR were higher in dogs with proteinuria and SCr < 1.4 mg/dL, whereas the serum cystatin C concentrations and RARI were higher only in dogs with SCr levels > 1.4. In conclusion, uGGT and uGGT/uCR may be useful tools for early detection and assessment of renal lesions associated with leishmaniasis; however, cystatin C is useful for monitoring the progression of kidney disease when measured sequentially. |
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فهرسة مساهمة: | Keywords: Cystatin C; Enzymuria; Leishmaniasis; Proteinuria; Resistance index |
المشرفين على المادة: | 0 (Biomarkers) 0 (Cystatin C) AYI8EX34EU (Creatinine) EC 2.3.2.2 (gamma-Glutamyltransferase) |
تواريخ الأحداث: | Date Created: 20180803 Date Completed: 20181218 Latest Revision: 20181218 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s00436-018-6032-2 |
PMID: | 30069827 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1955 |
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DOI: | 10.1007/s00436-018-6032-2 |