دورية أكاديمية
The association of BDNF gene polymorphism with cognitive impairment in insomnia patients.
| العنوان: | The association of BDNF gene polymorphism with cognitive impairment in insomnia patients. |
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| المؤلفون: | Zaki NFW; Sleep Research Unit, Mansoura University, Egypt; Department of Psychiatry, Mansoura University, Egypt. Electronic address: mernakero@mans.edu.eg., Saleh E; Department of Psychiatry, Mansoura University, Egypt., Elwasify M; Department of Psychiatry, Mansoura University, Egypt., Mahmoud E; Department of Psychiatry, Mansoura University, Egypt., Zaki J; Department 0f Mechanical Engineering, Statistical Consultation Office, Mansoura University, Egypt., Spence DW; Dufferin Street, Toronto, Canada., BaHammam AS; University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Pandi-Perumal SR; Somnogen Canada Inc., Toronto, Canada. |
| المصدر: | Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2019 Jan 10; Vol. 88, pp. 253-264. Date of Electronic Publication: 2018 Aug 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease*, Brain-Derived Neurotrophic Factor/*genetics , Cognition Disorders/*etiology , Cognition Disorders/*genetics , Polymorphism, Single Nucleotide/*genetics , Sleep Initiation and Maintenance Disorders/*complications, Adult ; Alleles ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Sleep Initiation and Maintenance Disorders/genetics ; Surveys and Questionnaires ; Young Adult |
| مستخلص: | Background: Reductions in BDNF activity have shown associations with depressed mood. Other evidence has demonstrated that the BDNF Val66Met polymorphism (rs6265) appears to reduce neural plasticity. A limited number of studies have investigated the influence of these genetic polymorphisms in insomnia. The present study sought to confirm the presence of associations between BDNF Val66Met polymorphism (rs6265) occurrence in normal sleepers and those with insomnia. Method: The study subjects consisted of a patient group (n = 199) complaining of insomnia and a control group (n = 51). Each subject was clinically interviewed using questions taken from the Brief Insomnia Questionnaire. After the interview, the subjects were asked to complete the Insomnia Severity Index, The Hamilton Depression Rating Scale, and the Montreal Cognitive Assessment Test. An overnight polysomnography test was also administered. Blood samples were collected for genetic study. Results: The insomnia patients showed a greater prevalence of heterozygous (A/G) VAL/MET polymorphism than the normal controls (p = ≤ 0.0001). This finding confirmed that this genetic polymorphism, which impairs BDNF activity, is an important correlate of disturbed sleep. Further, the finding of significantly greater (p = ≤ 0.0001) depression scores among the insomnia group suggested that BDNF is an important factor in the development of depressive symptoms. Clinical Implications: The results of the present study indicate that BDNF gene polymorphism plays a prominent role in the variation of symptoms among insomnia patients and, further, that this polymorphism is strongly related to the severity of depression. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: BDNF; Cognitive impairment; Gene polymorphism; Insomnia |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) |
| تواريخ الأحداث: | Date Created: 20180805 Date Completed: 20190318 Latest Revision: 20190318 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.pnpbp.2018.07.025 |
| PMID: | 30076879 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-4216 |
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| DOI: | 10.1016/j.pnpbp.2018.07.025 |