دورية أكاديمية
أعرض في EDS

The effect of Jun dimerization on neurite outgrowth and motif binding.

التفاصيل البيبلوغرافية
العنوان: The effect of Jun dimerization on neurite outgrowth and motif binding.
المؤلفون: Danzi MC; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Center for Computational Science, University of Miami, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Mehta ST; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Dulla K; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA., Zunino G; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Cooper DJ; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Bixby JL; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: jbixby@med.miami.edu., Lemmon VP; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Center for Computational Science, University of Miami, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: vlemmon@med.miami.edu.
المصدر: Molecular and cellular neurosciences [Mol Cell Neurosci] 2018 Oct; Vol. 92, pp. 114-127. Date of Electronic Publication: 2018 Aug 03.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9327 (Electronic) Linking ISSN: 10447431 NLM ISO Abbreviation: Mol Cell Neurosci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Diego : Academic Press, c1990-
مواضيع طبية MeSH: Neuronal Outgrowth* , Protein Multimerization*, Proto-Oncogene Proteins c-jun/*metabolism, Activating Transcription Factor 3/metabolism ; Animals ; Brain/cytology ; Brain/metabolism ; Cells, Cultured ; Enhancer Elements, Genetic ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/cytology ; Neurons/metabolism ; Protein Binding ; Rats ; Rats, Sprague-Dawley
مستخلص: Axon regeneration is a necessary step toward functional recovery after spinal cord injury. The AP-1 transcription factor c-Jun has long been known to play an important role in directing the transcriptional response of Dorsal Root Ganglion (DRG) neurons to peripheral axotomy that results in successful axon regeneration. Here we performed ChIPseq for Jun in mouse DRG neurons after a sciatic nerve crush or sham surgery in order to measure the changes in Jun's DNA binding in response to peripheral axotomy. We found that the majority of Jun's injury-responsive changes in DNA binding occur at putative enhancer elements, rather than proximal to transcription start sites. We also used a series of single polypeptide chain tandem transcription factors to test the effects of different Jun-containing dimers on neurite outgrowth in DRG, cortical and hippocampal neurons. These experiments demonstrated that dimers composed of Jun and Atf3 promoted neurite outgrowth in rat CNS neurons as well as mouse DRG neurons. Our work provides new insight into the mechanisms underlying Jun's role in axon regeneration.
(Copyright © 2018. Published by Elsevier Inc.)
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معلومات مُعتمدة: R01 HD039884 United States HD NICHD NIH HHS; R01 HD057632 United States HD NICHD NIH HHS; R25 NS083064 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: AP-1; Chromatin immunoprecipitation; Dorsal Root Ganglion; Enhancer
المشرفين على المادة: 0 (Activating Transcription Factor 3)
0 (Proto-Oncogene Proteins c-jun)
تواريخ الأحداث: Date Created: 20180806 Date Completed: 20190305 Latest Revision: 20200807
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6547139
DOI: 10.1016/j.mcn.2018.08.001
PMID: 30077771
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9327
DOI:10.1016/j.mcn.2018.08.001