دورية أكاديمية
أعرض في EDS

Associations between long-term exposure to air pollution, glycosylated hemoglobin, fasting blood glucose and diabetes mellitus in northern France.

التفاصيل البيبلوغرافية
العنوان: Associations between long-term exposure to air pollution, glycosylated hemoglobin, fasting blood glucose and diabetes mellitus in northern France.
المؤلفون: Riant M; CHU Lille, Epidemiology, Health Economics and Prevention Service, F-59000 Lille, France., Meirhaeghe A; Inserm UMR1167 - RID-AGE Risk Factors and Molecular Determinants of Aging-related Diseases, Institut Pasteur de Lille, Université de Lille, Lille, France., Giovannelli J; Inserm UMR1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université de Lille, Centre Hosp. Univ Lille, Institut Pasteur de Lille, Lille, France., Occelli F; Univ. Lille, EA4483 - IMPECS (IMPact of Environmental ChemicalS on Human Health), F-59000 Lille, France., Havet A; CHU Lille, Epidemiology, Health Economics and Prevention Service, F-59000 Lille, France; Univ. Lille, EA4483 - IMPECS (IMPact of Environmental ChemicalS on Human Health), F-59000 Lille, France., Cuny D; Univ. Lille, EA4483 - IMPECS (IMPact of Environmental ChemicalS on Human Health), F-59000 Lille, France., Amouyel P; Inserm UMR1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université de Lille, Centre Hosp. Univ Lille, Institut Pasteur de Lille, Lille, France., Dauchet L; Inserm UMR1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université de Lille, Centre Hosp. Univ Lille, Institut Pasteur de Lille, Lille, France. Electronic address: luc.dauchet@chru-lille.fr.
المصدر: Environment international [Environ Int] 2018 Nov; Vol. 120, pp. 121-129. Date of Electronic Publication: 2018 Aug 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
أسماء مطبوعة: Publication: : Amsterdam : Elsevier Science
Original Publication: Oxford; Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/epidemiology , Environmental Exposure*/analysis , Environmental Exposure*/statistics & numerical data, Air Pollutants/*analysis , Blood Glucose/*analysis , Glycated Hemoglobin/*analysis, Adult ; Aged ; Cross-Sectional Studies ; France/epidemiology ; Humans ; Middle Aged
مستخلص: Introduction: A growing body of evidence suggests that long-term exposure to air pollutants like nitrogen oxides (NO x ) and particulate matter (PM) is associated with the prevalence and incidence of type 2 diabetes mellitus. Serum glucose and glycosylated hemoglobin (HbA1c) levels are biomarkers of glucose homeostasis. Data on the association between glucose homeostasis biomarkers and air pollution are scarce. HbA1c and fasting blood glucose (FBG) concentrations have been linked to PM and NO 2 exposure in Taiwan, where mean pollution levels are 3 to 7 times higher than the guideline maximum annual mean values of 40 μg/m 3 (for NO 2 ) and 20 μg/m 3 (for PM10) set by the World Health Organization (WHO). However, this association is not consistently reported at lower levels of pollution. The objective of the present study was to investigate the relationships between long-term exposure to air pollution at the place of residence, diabetes biomarkers, and prevalent diabetes in two cities with relatively low level of pollution.
Methods: Data were recorded for 2895 adults (aged 40 to 65) having participated in the 2011-2013 ELISABET cross-sectional survey of the Lille and Dunkirk urban areas in northern France. Using multiple logistic and generalized linear regression models, we analyzed the associations between individual exposure to pollution on one hand and HbA1c, FBG and prevalent diabetes mellitus (DM) on the other. An atmospheric dispersion modelling system was used to assess annual exposure at the place of residence to coarse particulate matter (PM10), NO 2 , and sulfur dioxide (SO 2 ).
Results: The median pollutant levels were 21.96 μg/m 3 for NO 2 , 26.75 μg/m 3 for PM10, and 3.07 μg/m 3 for SO 2 . A 2 μg/m 3 increment in PM10 was associated with an HbA1c increment [95% confidence interval] of 0.044% [0.021; 0.067]. This association was still statistically significant after adjustment for the neighborhood's characteristics. A 5 μg/m 3 increment in NO 2 was associated with an HbA1c increment of 0.031% [0.010; 0.053]. Associations between DM or FBG and air pollution did not achieve statistical significance.
Conclusion: Our study of a middle-aged, urban population evidenced an association between elevated HbA1c levels and long-term exposure to PM10 and NO 2 pollution levels that were relatively low but close to the WHO's guideline maximum values.
(Copyright © 2018. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Air pollution; Cross-sectional study; Diabetes mellitus; Epidemiology; Fasting blood glucose; Glycosylated hemoglobin
المشرفين على المادة: 0 (Air Pollutants)
0 (Blood Glucose)
0 (Glycated Hemoglobin A)
تواريخ الأحداث: Date Created: 20180806 Date Completed: 20190305 Latest Revision: 20221207
رمز التحديث: 20221213
DOI: 10.1016/j.envint.2018.07.034
PMID: 30077944
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6750
DOI:10.1016/j.envint.2018.07.034