دورية أكاديمية
أعرض في EDS

Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion.

التفاصيل البيبلوغرافية
العنوان: Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion.
المؤلفون: Landa SB; Division of Molecular and Radiation Biophysics, National Research Center , Gatchina, 188300, Russian Federation., Korabliov PV; State Research Institute Center for Innovative Medicine, Vilnius, LT-01102, Lithuania., Semenova EV; Division of Molecular and Radiation Biophysics, National Research Center , Gatchina, 188300, Russian Federation., Filatov MV; Division of Molecular and Radiation Biophysics, National Research Center , Gatchina, 188300, Russian Federation.; Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, 191036, Russian Federation.
المصدر: F1000Research [F1000Res] 2018 May 21; Vol. 7, pp. 618. Date of Electronic Publication: 2018 May 21 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Print ISSN: 2046-1402 (Print) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : F1000 Research Ltd
مستخلص: Background: Large protein aggregates, known as circulating immune complexes (CICs), are formed in biological fluids as a result of the development of the body's immune response to various provoking factors. The kinetic characteristics of the formation and removal of immune complexes (ICs), their physical parameters, the isotypic composition of immunoglobulins (Igs) and the antigenic component of the CICs may reflect certain aspects of certain pathological and metabolic processes taking place in humans and animals. The aim of this study is to assess the kinetic characteristics of the formation and removal of the CICs that form in blood after eating. We also analyze the changes in the isotypic composition of Igs of ICs that accompany this biological process in rodents and humans. Methods: We identified the CICs, which differed in size and class of Igs, using dynamic light scattering. To remove ICs from the plasma, we used immune-affinity sedimentation. Monoclonal antibodies for the Igs of different isotypes were added to the plasma samples to determine the isotypic composition of the ICs. Results: A large number of ICs were formed in the blood of rats and humans after eating (food CICs). In rats, food ICs are almost immediately filtered in the liver, without circulating in the bloodstream through the body. In humans, the level of food ICs in the blood increases for 3.5 h after ingestion, then within 7-8 h their gradual removal takes place. It was found that in the process of digestion in humans, the isotypic composition of Igs in the CICs changes and becomes more diverse. Conclusions: The molecular-cellular mechanisms of the formation and utilization of food CICs in humans and rodents do not match completely.
Competing Interests: No competing interests were disclosed.
References: Semin Immunopathol. 2012 Sep;34(5):633-42. (PMID: 22777546)
J Immunol. 2001 Mar 15;166(6):3688-92. (PMID: 11238608)
Mol Immunol. 2005 May;42(7):781-7. (PMID: 15829266)
Am J Transl Res. 2016 Feb 15;8(2):749-64. (PMID: 27158367)
Przegl Lek. 2012;69(10):737-9. (PMID: 23421022)
J Korean Med Sci. 1996 Jun;11(3):217-21. (PMID: 8843003)
Semin Nephrol. 1992 Sep;12(5):379-94. (PMID: 1410864)
Wiad Lek. 2004;57(3-4):123-30. (PMID: 15307518)
Clin Vaccine Immunol. 2006 Feb;13(2):258-65. (PMID: 16467335)
Physiol Rev. 2006 Jan;86(1):279-367. (PMID: 16371600)
J Investig Allergol Clin Immunol. 1999 May-Jun;9(3):183-9. (PMID: 10412681)
J Immunol. 2000 Feb 15;164(4):1952-60. (PMID: 10657645)
Microbes Infect. 2001 Oct;3(12):1021-35. (PMID: 11580989)
Clin Rheumatol. 2013 Sep;32(9):1255-66. (PMID: 23708831)
Blood. 2008 Aug 15;112(4):1091-100. (PMID: 18539895)
J Immunol Methods. 2000 Apr 3;237(1-2):1-17. (PMID: 10725447)
Przegl Lek. 1995;52(8):375-81. (PMID: 8525007)
Arthritis Res Ther. 2015 Jan 19;17:8. (PMID: 25598326)
Biol Pharm Bull. 2012;35(9):1409-12. (PMID: 22975488)
F1000Res. 2018 May 21;7:618. (PMID: 30079242)
J Cancer Res Ther. 2012 Jan;8 Suppl 1:S116-22. (PMID: 22322729)
Nat Med. 2002 Mar;8(3):295-301. (PMID: 11875502)
J Am Soc Nephrol. 2005 Jul;16(7):2088-97. (PMID: 15930092)
Clin Chem. 2011 Jun;57(6):905-9. (PMID: 21482748)
Lupus. 2011 Nov;20(13):1396-403. (PMID: 22095887)
Adv Clin Chem. 2013;60:129-41. (PMID: 23724743)
Curr Allergy Asthma Rep. 2013 Dec;13(6):596-606. (PMID: 24013944)
Indian J Dent Res. 2010 Jan-Mar;21(1):10-5. (PMID: 20427899)
Klin Lab Diagn. 2008 Apr;(4):37-41. (PMID: 18619204)
Methods Mol Biol. 2014;1134:47-57. (PMID: 24497353)
Physiol Rev. 2003 Jul;83(3):871-932. (PMID: 12843411)
Circulation. 2009 Nov 17;120(20):2012-24. (PMID: 19917895)
Immunol Res. 2003;28(3):265-84. (PMID: 14713719)
Clin Immunol Immunopathol. 1997 Mar;82(3):250-7. (PMID: 9073548)
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt B):256-276. (PMID: 27496705)
Biochemistry (Mosc). 2009 May;74(5):469-79. (PMID: 19538120)
Semin Nephrol. 2008 Jan;28(1):78-87. (PMID: 18222349)
Microbiology (Reading). 2004 Nov;150(Pt 11):3807-3819. (PMID: 15528666)
Appl Opt. 1997 Oct 20;36(30):7518-22. (PMID: 18264264)
Immunol Rev. 2005 Aug;206:64-82. (PMID: 16048542)
J Immunol. 2007 Jan 1;178(1):27-32. (PMID: 17182536)
Nat Rev Immunol. 2001 Oct;1(1):59-67. (PMID: 11905815)
Parasite Immunol. 2008 Jun-Jul;30(6-7):334-41. (PMID: 18466201)
PLoS One. 2012;7(9):e44824. (PMID: 22984570)
فهرسة مساهمة: Keywords: digestion; dynamic light scattering method; isotypes of immunoglobulins; сirculating immune complexes
تواريخ الأحداث: Date Created: 20180807 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC6058468
DOI: 10.12688/f1000research.14406.1
PMID: 30079242
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-1402
DOI:10.12688/f1000research.14406.1