دورية أكاديمية

Fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.

التفاصيل البيبلوغرافية
العنوان: Fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
المؤلفون: Abd El-Aal EB; a Faculty of Medicine , Al-Azhar University , Cairo , Egypt., Abdo HM; a Faculty of Medicine , Al-Azhar University , Cairo , Egypt., Ibrahim SM; a Faculty of Medicine , Al-Azhar University , Cairo , Egypt., Eldestawy MT; a Faculty of Medicine , Al-Azhar University , Cairo , Egypt.
المصدر: The Journal of dermatological treatment [J Dermatolog Treat] 2019 May; Vol. 30 (3), pp. 277-282. Date of Electronic Publication: 2018 Sep 28.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: Houndmills, Basingstoke, Hampshire, UK : M. Dunitz and Macmillan Press, [c1989]-
مواضيع طبية MeSH: Lasers, Gas*, Antifungal Agents/*administration & dosage , Imidazoles/*administration & dosage , Nicotinic Acids/*administration & dosage , Onychomycosis/*drug therapy, Administration, Topical ; Adult ; Aged ; Antifungal Agents/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome
مستخلص: Background: Onychomycosis is a chronic fungal infection of the nails, and the treatment has been proven to be a challenge to healthcare professionals.
Objective: To evaluate the efficacy of fractional carbon dioxide laser-assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
Materials and Methods: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, and both groups were treated with four sessions of fractional CO 2 laser and followed by topical tazarotene 0.1% in Group A and topical tioconazole 28% in Group B. The clinical effect, KOH examination, and culture for the affected nails in the two groups were analyzed.
Results: One month after the last session, regarding clinical response, 35.3% showed complete improvement in Group A versus 33.3% in Group B without significant difference. There was a significant difference between the two studied groups as regards KOH test and culture result before and after treatment (p value<.001), they were turned negative in 91.7% and 100% of patients in Group A and 78.3% and 95.5% of patients in Group B, respectively.
Conclusion: Fractional CO 2 laser-assisted drug delivery is an effective and safe treatment option for onychomycosis.
فهرسة مساهمة: Keywords: Fractional CO; onychomycosis; tazarotene; tioconazole
المشرفين على المادة: 0 (Antifungal Agents)
0 (Imidazoles)
0 (Nicotinic Acids)
81BDR9Y8PS (tazarotene)
S57Y5X1117 (tioconazole)
تواريخ الأحداث: Date Created: 20180808 Date Completed: 20190610 Latest Revision: 20190613
رمز التحديث: 20231215
DOI: 10.1080/09546634.2018.1509046
PMID: 30081698
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-1753
DOI:10.1080/09546634.2018.1509046