دورية أكاديمية
أعرض في EDS

Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor.

التفاصيل البيبلوغرافية
العنوان: Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor.
المؤلفون: Hong D; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont.; Graduate Program in Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts., Fritz AJ; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Finstad KH; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Fitzgerald MP; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Weinheimer A; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Viens AL; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Ramsey J; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Stein JL; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Lian JB; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont., Stein GS; Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont. gary.stein@uvm.edu.
المصدر: Molecular cancer research : MCR [Mol Cancer Res] 2018 Dec; Vol. 16 (12), pp. 1952-1964. Date of Electronic Publication: 2018 Aug 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : American Association for Cancer Research, c2002-
مواضيع طبية MeSH: Breast Neoplasms/*pathology , Core Binding Factor Alpha 2 Subunit/*genetics , Core Binding Factor Alpha 2 Subunit/*metabolism , Neoplastic Stem Cells/*metabolism , Zinc Finger E-box-Binding Homeobox 1/*metabolism, Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Mice ; Neoplasm Staging ; Neoplasm Transplantation ; Survival Analysis
مستخلص: Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand the mechanisms underlying this cancer. Cancer stem cells (CSC) play an important role in tumor formation, growth, drug resistance, and recurrence. Here, it is demonstrated that the transcription factor RUNX1, well known as essential for hematopoietic differentiation, represses the breast cancer stem cell (BCSC) phenotype and suppresses tumor growth in vivo . The current studies show that BCSCs sorted from premalignant breast cancer cells exhibit decreased RUNX1 levels, whereas ectopic expression of RUNX1 suppresses tumorsphere formation and reduces the BCSC population. RUNX1 ectopic expression in breast cancer cells reduces migration, invasion, and in vivo tumor growth (57%) in mouse mammary fat pad. Mechanistically, RUNX1 functions to suppress breast cancer tumor growth through repression of CSC activity and direct inhibition of ZEB1 expression. Consistent with these cellular and biochemical results, clinical findings using patient specimens reveal that the highest RUNX1 levels occur in normal mammary epithelial cells and that low RUNX1 expression in tumors is associated with poor patient survival. IMPLICATIONS: The key finding that RUNX1 represses stemness in several breast cancer cell lines points to the importance of RUNX1 in other solid tumors where RUNX1 may regulate CSC properties.
(©2018 American Association for Cancer Research.)
References: Oncotarget. 2017 Mar 14;8(11):17610-17627. (PMID: 28407681)
Semin Cancer Biol. 2012 Oct;22(5-6):396-403. (PMID: 22554795)
Nature. 2012 Jun 20;486(7403):405-9. (PMID: 22722202)
Front Med. 2012 Sep;6(3):248-62. (PMID: 22875638)
Oncogene. 2010 Aug 26;29(34):4741-51. (PMID: 20531305)
Breast Cancer Res. 2008;10(2):R25. (PMID: 18366788)
CA Cancer J Clin. 2015 Mar;65(2):87-108. (PMID: 25651787)
Nat Commun. 2016 Feb 26;7:10751. (PMID: 26916619)
Oncogene. 2005 Nov 17;24(51):7579-91. (PMID: 16044150)
Clin Transl Med. 2013 Jan 17;2(1):3. (PMID: 23369605)
Science. 2015 Jan 23;347(6220):1260419. (PMID: 25613900)
Pharmacol Ther. 2016 Apr;160:145-58. (PMID: 26899500)
J Cell Biol. 2011 Apr 4;193(1):235-50. (PMID: 21464233)
Oncogene. 2004 May 24;23(24):4198-208. (PMID: 15156173)
PLoS One. 2010 Feb 15;5(2):e9201. (PMID: 20169162)
Nat Commun. 2016 May 10;7:11479. (PMID: 27161491)
EMBO J. 2012 Nov 5;31(21):4124-39. (PMID: 23034403)
Blood. 2017 Apr 13;129(15):2061-2069. (PMID: 28179276)
Nat Commun. 2016 Feb 15;7:10498. (PMID: 26876920)
World J Stem Cells. 2015 Oct 26;7(9):1150-84. (PMID: 26516408)
Nat Rev Clin Oncol. 2017 Oct;14(10):611-629. (PMID: 28397828)
Cancer Metastasis Rev. 2016 Dec;35(4):645-654. (PMID: 27878502)
Elife. 2014 Nov 21;3:e03881. (PMID: 25415051)
Blood Cells Mol Dis. 2010 Apr 15;44(4):275-86. (PMID: 20144877)
Nature. 2012 Oct 4;490(7418):61-70. (PMID: 23000897)
EMBO J. 1994 Feb 1;13(3):504-10. (PMID: 8313895)
Blood. 2009 Sep 24;114(13):2744-52. (PMID: 19638627)
Mol Cell Biol. 2010 May;30(10):2518-36. (PMID: 20308320)
Biochim Biophys Acta. 2016 Nov;1859(11):1389-1397. (PMID: 27514584)
Clin Cancer Res. 2007 Jun 1;13(11):3207-14. (PMID: 17545524)
Nat Cell Biol. 2017 May;19(5):518-529. (PMID: 28414315)
J Cell Physiol. 2015 Oct;230(10):2522-32. (PMID: 25802202)
J Clin Med. 2016 Apr 29;5(5):. (PMID: 27136592)
Curr Pharm Des. 2015;21(10):1301-10. (PMID: 25506895)
Nat Rev Cancer. 2008 Oct;8(10):755-68. (PMID: 18784658)
Nat Rev Drug Discov. 2014 Jul;13(7):497-512. (PMID: 24981363)
BMC Cancer. 2014 Dec 17;14:970. (PMID: 25518851)
J Clin Bioinforma. 2013 Oct 28;3(1):22. (PMID: 24165311)
Oncotarget. 2016 Feb 9;7(6):6552-65. (PMID: 26735887)
Cell Cycle. 2015;14(4):481-7. (PMID: 25607528)
Cancer Biomark. 2012-2013;12(3):125-33. (PMID: 23481571)
Nat Rev Cancer. 2015 Feb;15(2):81-95. (PMID: 25592647)
J Clin Invest. 2014 Jan;124(1):398-412. (PMID: 24316975)
Nature. 2012 Jun 10;486(7403):353-60. (PMID: 22722193)
CA Cancer J Clin. 2017 Jan;67(1):7-30. (PMID: 28055103)
Methods Mol Biol. 2010;649:437-55. (PMID: 20680851)
PLoS Comput Biol. 2015 Apr 20;11(4):e1004161. (PMID: 25894653)
Gastroenterology. 2017 Jan;152(1):218-231.e14. (PMID: 27670082)
Nature. 2013 Sep 19;501(7467):328-37. (PMID: 24048065)
Oncogene. 1998 Oct 8;17(14):1813-20. (PMID: 9778047)
معلومات مُعتمدة: F32 CA220935 United States CA NCI NIH HHS; R37 DE012528 United States DE NIDCR NIH HHS; P01 CA082834 United States CA NCI NIH HHS; U01 CA196383 United States CA NCI NIH HHS; R01 CA139322 United States CA NCI NIH HHS; R56 DE012528 United States DE NIDCR NIH HHS; U54 GM115516 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Core Binding Factor Alpha 2 Subunit)
0 (RUNX1 protein, human)
0 (ZEB1 protein, human)
0 (Zinc Finger E-box-Binding Homeobox 1)
تواريخ الأحداث: Date Created: 20180808 Date Completed: 20190828 Latest Revision: 20231004
رمز التحديث: 20231004
مُعرف محوري في PubMed: PMC6289193
DOI: 10.1158/1541-7786.MCR-18-0135
PMID: 30082484
قاعدة البيانات: MEDLINE
الوصف
تدمد:1557-3125
DOI:10.1158/1541-7786.MCR-18-0135