دورية أكاديمية
أعرض في EDS

In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp) 3 and La(XT), for the treatment of bone resorption disorders.

التفاصيل البيبلوغرافية
العنوان: In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp) 3 and La(XT), for the treatment of bone resorption disorders.
المؤلفون: Cawthray JF; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Place , Saskatoon , SK S7N 2Z4 , Canada . Email: kishor.wasan@usask.ca., Weekes DM; Medicinal Inorganic Chemistry Group , Department of Chemistry , University of British Columbia , 2036 Main Mall , Vancouver , BC V6T 1Z1 , Canada . Email: orvig@chem.ubc.ca., Sivak O; Faculty of Pharmaceutical Sciences , University of British Columbia , 2146 East Mall , Vancouver , BC V6T 1Z3 , Canada., Creagh AL; Michael Smith Laboratories and Department of Chemical and Biological Engineering , University of British Columbia , Vancouver , BC V6T 1Z4 , Canada., Ibrahim F; Pfizer Inc. , Eastern Point Road , Groton , CT 06340 , USA., Iafrate M; Medicinal Inorganic Chemistry Group , Department of Chemistry , University of British Columbia , 2036 Main Mall , Vancouver , BC V6T 1Z1 , Canada . Email: orvig@chem.ubc.ca., Haynes CA; Michael Smith Laboratories and Department of Chemical and Biological Engineering , University of British Columbia , Vancouver , BC V6T 1Z4 , Canada., Wasan KM; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Place , Saskatoon , SK S7N 2Z4 , Canada . Email: kishor.wasan@usask.ca., Orvig C; Medicinal Inorganic Chemistry Group , Department of Chemistry , University of British Columbia , 2036 Main Mall , Vancouver , BC V6T 1Z1 , Canada . Email: orvig@chem.ubc.ca.
المصدر: Chemical science [Chem Sci] 2015 Nov 01; Vol. 6 (11), pp. 6439-6447. Date of Electronic Publication: 2015 Aug 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : Royal Society of Chemistry, [2010]-
مستخلص: Bone density diseases such as osteoporosis affect a significant number of people worldwide. Lanthanide ions are functional mimics of calcium ions, able to substitute for Ca 2+ in the bone mineral component, hydroxyapatite (HAP). Bone undergoes a continuous remodelling cycle and lanthanides can affect this cycle, exerting a positive influence on bone mineral. We have been engaged in efforts to find new lanthanide containing complexes as active agents for treatment of these diseases and have identified two lead compounds, 3-hydroxy-1,2-dimethylpyridin-4(1 H )-one (Hdpp) and a phosphinate-EDTA derivative, bis[[bis(carboxymethyl)amino]-methyl]phosphinate (H 5 XT). In this paper, we report in vivo data for the first time for the two lead compounds. The pharmacokinetics of La(dpp) 3 suggest the complex is rapidly cleared from plasma. We demonstrate that La 3+ accumulates in the bone following IV dose of either La(dpp) 3 or La(XT) and we have investigated the influence of each chelating ligand on the incorporation of La 3+ into HAP using ITC and HAP-binding studies.
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تواريخ الأحداث: Date Created: 20180810 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC6054118
DOI: 10.1039/c5sc01767j
PMID: 30090262
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-6520
DOI:10.1039/c5sc01767j