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Possible role of nicotine and cotinine on nitroxidative stress and antioxidant content in saliva of smokeless tobacco consumers.

التفاصيل البيبلوغرافية
العنوان: Possible role of nicotine and cotinine on nitroxidative stress and antioxidant content in saliva of smokeless tobacco consumers.
المؤلفون: Begum SF; Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India., Nagajothi G; Department of Corporate Secretaryship, Queen Mary's College (Autonomous), Chennai 600004, Tamilnadu, India., Latha KS; Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India., Sandeep G; Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India., Sreekanth B; Department of Zoology, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India., Kumar CS; Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India., Rajendra W; Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India., Maddu N; Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India.
المصدر: Practical laboratory medicine [Pract Lab Med] 2018 Jul 17; Vol. 12, pp. e00105. Date of Electronic Publication: 2018 Jul 17 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690848 Publication Model: eCollection Cited Medium: Print ISSN: 2352-5517 (Print) Linking ISSN: 23525517 NLM ISO Abbreviation: Pract Lab Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2015]-
مستخلص: The aim of the study is to levels of nicotine and cotinine were elevated the oxidative stress malondialdehyde (MDA) and inflammation as nitric oxide (NO 2 and NO 3 ) may possibly be associated with decreased antioxidant enzyme activities and can sensitively indicate the production of reactive oxygen species (ROS). To evaluate the quantitative analysis of nicotine and cotinine levels and the alterations in the selected parameters of antioxidant metabolisms during nitroxidative stress in the saliva of smokeless tobacco consumers. Saliva nicotine and cotinine was measured by HPLC method and nitric oxide, lipid peroxidation and activities of antioxidant enzymes were estimated by spectrophotometric methods. Significant increase in concentrations of nicotine and cotinine levels of saliva in smokeless tobacco users in comparison to controls. Saliva lipid peroxidation was increased in experimental subjects (gutkha group 39.28% and khaini group 25.00%) as compared to controls and nitric oxide in the form of nitrites and nitrates was significantly increased in the saliva of smokeless tobacco users compared to controls. The activity levels of antioxidant enzymes were decreased in the saliva of the smokeless tobacco users in comparison with normal controls. A strong positive correlation of nicotine and cotinine with nitroxidative stress markers in gutkha and khaini users. Increased expression of inducible nitric oxide synthase (iNOS) enzyme leads to intoxication in saliva and indirectly induces inflammation process. Increased production of reactive oxygen species (ROS) and decrease in the activity levels of antioxidant enzymes in the saliva of smokeless tobacco users indicate conspicuous cell and tissue damage.
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فهرسة مساهمة: Keywords: Antioxidant enzymes; CAT, Catalase; Cotinine; DCM, Dichloromethane; DEE, Diethyl ether; Free radicals; GPx, Glutathione peroxidase; GSH, Reduced glutathione; GST, Glutathione S-Transferase; MDA, malondialdehyde; NOS, Nitric oxide synthase; Nicotine; RNS, Reactive nitrogen species; ROS, Reactive oxygen species; RP-HPLC; SLT, Smokeless tobacco; SOD, Superoxide dismutase; Smokeless tobacco; TBA, Thiobarbituric acid; TBARS, Thiobarbituric acid reacting substance; TCA, Trichloro acetic acid; TSNA, Tobacco- specific nitrosamines; eNOS, Endothelial nitric oxide synthase; iNOS, Inducible nitric oxide synthase; nNOS, Neuronal nitric oxide synthase
تواريخ الأحداث: Date Created: 20180810 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC6078104
DOI: 10.1016/j.plabm.2018.e00105
PMID: 30090844
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-5517
DOI:10.1016/j.plabm.2018.e00105