دورية أكاديمية
أعرض في EDS

Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.

التفاصيل البيبلوغرافية
العنوان: Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.
المؤلفون: Lanzer KG; Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983 USA., Cookenham T; Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983 USA., Reiley WW; Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983 USA., Blackman MA; Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983 USA.
المصدر: Immunity & ageing : I & A [Immun Ageing] 2018 Aug 08; Vol. 15, pp. 17. Date of Electronic Publication: 2018 Aug 08 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101235427 Publication Model: eCollection Cited Medium: Print ISSN: 1742-4933 (Print) Linking ISSN: 17424933 NLM ISO Abbreviation: Immun Ageing Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, [2004]-
مستخلص: Background: A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells. We have hypothesized that the age-related decline in naïve T cells forces the immune system to respond to new infections using cross-reactive memory T cells generated to previous infections that dominate the aged peripheral T cell repertoire.
Results: Here we confirm that the CD8 T cell response of aged, influenza-naïve mice to primary infection with influenza virus is dominated by T cells that derive from the memory T cell pool. These cells exhibit the phenotypic characteristics of virtual memory cells rather than true memory cells. Furthermore, we find that the repertoire of responding CD8 T cells is constrained compared with that of young mice, and differs significantly between individual aged mice. After infection, these virtual memory CD8 T cells effectively develop into granzyme-producing effector cells, and clear virus with kinetics comparable to naïve CD8 T cells from young mice.
Conclusions: The response of aged, influenza-naive mice to a new influenza infection is mediated largely by memory CD8 T cells. However, unexpectedly, they have the phenotype of VM cells. In response to de novo influenza virus infection, the VM cells develop into granzyme-producing effector cells and clear virus with comparable kinetics to young CD8 T cells.
Competing Interests: Animal housing and procedures were approved by the Animal Care and Use Committee of Trudeau Institute.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
التعليقات: Erratum in: Immun Ageing. 2018 Aug 21;15:18. (PMID: 30166990)
References: Nat Immunol. 2006 May;7(5):475-81. (PMID: 16604076)
Cell. 2017 Nov 16;171(5):1015-1028.e13. (PMID: 29056339)
Eur J Immunol. 1989 Jun;19(6):977-82. (PMID: 2666144)
Nat Immunol. 2002 Jul;3(7):627-34. (PMID: 12055626)
J Immunol. 2009 Sep 1;183(5):3364-72. (PMID: 19675163)
J Exp Med. 2005 Feb 21;201(4):523-33. (PMID: 15710651)
Cell. 2015 May 7;161(4):702-4. (PMID: 25957676)
Immun Ageing. 2011 Aug 16;8:6. (PMID: 21846352)
J Immunol. 2005 Jun 1;174(11):7446-52. (PMID: 15905594)
Nat Rev Immunol. 2017 Jun;17(6):391-400. (PMID: 28480897)
Nat Immunol. 2016 Aug;17(8):966-75. (PMID: 27270402)
Immunol Today. 1998 Sep;19(9):395-404. (PMID: 9745202)
Trends Immunol. 2011 Feb;32(2):50-6. (PMID: 21288770)
Science. 1999 Oct 29;286(5441):958-61. (PMID: 10542151)
Nat Rev Immunol. 2004 Feb;4(2):123-32. (PMID: 15040585)
J Immunol. 2000 Sep 1;165(5):2367-73. (PMID: 10946259)
J Immunol. 2006 Feb 15;176(4):2645-53. (PMID: 16456027)
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13498-503. (PMID: 23898211)
Immunol Rev. 2010 May;235(1):244-66. (PMID: 20536568)
Immunity. 2004 Jan;20(1):5-16. (PMID: 14738760)
J Immunol. 2009 Jan 15;182(2):784-92. (PMID: 19124721)
Mol Immunol. 2002 Mar;38(11):841-8. (PMID: 11922942)
Nat Commun. 2016 Apr 21;7:11291. (PMID: 27097762)
Cell Host Microbe. 2016 May 11;19(5):713-9. (PMID: 27107939)
Immunology. 2014 Jun;142(2):167-75. (PMID: 24405293)
Nat Commun. 2017 May 03;8:14811. (PMID: 28466840)
J Virol. 2015 Apr;89(8):4102-16. (PMID: 25609818)
J Immunol. 2012 Mar 15;188(6):2516-23. (PMID: 22308307)
Trends Immunol. 2006 Jul;27(7):303-7. (PMID: 16731040)
J Immunol. 2013 Dec 15;191(12):5793-6. (PMID: 24227783)
Science. 2002 Nov 29;298(5599):1797-800. (PMID: 12459592)
Curr Opin Immunol. 2005 Oct;17(5):468-75. (PMID: 16098723)
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13694-9. (PMID: 21813761)
J Exp Med. 2004 Nov 15;200(10):1347-58. (PMID: 15545358)
J Immunol. 2012 Feb 15;188(4):1933-41. (PMID: 22246631)
Front Immunol. 2012 Nov 27;3:357. (PMID: 23230439)
J Immunol. 2000 Jun 1;164(11):5782-7. (PMID: 10820256)
Microbes Infect. 2002 Apr;4(5):539-45. (PMID: 11959509)
Semin Immunol. 2004 Oct;16(5):335-47. (PMID: 15528078)
Immunity. 2013 Feb 21;38(2):373-83. (PMID: 23395677)
Virology. 2015 Aug;482:89-97. (PMID: 25838115)
J Immunol. 1989 Jul 15;143(2):558-64. (PMID: 2472444)
J Virol. 2000 Apr;74(8):3486-93. (PMID: 10729122)
J Immunol. 2014 Mar 15;192(6):2689-98. (PMID: 24510963)
Annu Rev Immunol. 2004;22:711-43. (PMID: 15032594)
PLoS Pathog. 2012 Feb;8(2):e1002544. (PMID: 22383879)
Immun Ageing. 2008 Nov 12;5:14. (PMID: 19014475)
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13139-44. (PMID: 25157137)
Annu Rev Immunol. 2005;23:651-82. (PMID: 15771583)
Curr Opin Immunol. 2011 Aug;23(4):537-42. (PMID: 21652194)
Exp Gerontol. 2017 Oct 1;96:29-37. (PMID: 28535950)
J Immunol. 2014 Jan 1;192(1):151-9. (PMID: 24293630)
Semin Immunol. 2004 Jun;16(3):171-7. (PMID: 15130501)
Nature. 1999 Oct 14;401(6754):708-12. (PMID: 10537110)
J Immunol. 2010 Sep 15;185(6):3456-62. (PMID: 20720204)
J Exp Med. 2008 Mar 17;205(3):711-23. (PMID: 18332179)
J Exp Med. 2009 Feb 16;206(2):435-48. (PMID: 19188498)
J Immunol. 1993 Dec 15;151(12):6657-69. (PMID: 8258683)
Genome Med. 2015 Nov 19;7(1):117. (PMID: 26582264)
J Exp Med. 2009 Nov 23;206(12):2735-45. (PMID: 19901080)
J Immunol. 2006 Sep 1;177(5):2888-98. (PMID: 16920924)
Annu Rev Immunol. 2004;22:745-63. (PMID: 15032595)
Nature. 2016 Apr 28;532(7600):512-6. (PMID: 27096360)
J Exp Med. 1994 Feb 1;179(2):609-18. (PMID: 8294871)
Crit Rev Immunol. 2003;23(1-2):45-64. (PMID: 12906259)
Adv Immunol. 2015;126:173-213. (PMID: 25727290)
Respir Res. 2009 Nov 18;10:112. (PMID: 19922665)
Clin Exp Immunol. 2017 Jan;187(1):71-81. (PMID: 27324743)
J Immunol. 2012 Dec 1;189(11):5356-66. (PMID: 23087407)
Science. 2001 Mar 23;291(5512):2413-7. (PMID: 11264538)
J Immunol. 2010 Jun 15;184(12):6739-45. (PMID: 20483749)
Immunity. 2014 Jul 17;41(1):127-40. (PMID: 25035957)
J Exp Med. 2003 Aug 4;198(3):399-410. (PMID: 12885871)
معلومات مُعتمدة: P01 AG021600 United States AG NIA NIH HHS; R01 AG039485 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Ageing; Influenza; Mouse model; T cell receptor repertoire; True memory (TM) T cells; Virtual memory (VM) T cells
تواريخ الأحداث: Date Created: 20180811 Latest Revision: 20220318
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6081820
DOI: 10.1186/s12979-018-0122-y
PMID: 30093911
قاعدة البيانات: MEDLINE
الوصف
تدمد:1742-4933
DOI:10.1186/s12979-018-0122-y