دورية أكاديمية
أعرض في EDS

Human CD8 T-cell activation in acute and chronic chikungunya infection.

التفاصيل البيبلوغرافية
العنوان: Human CD8 T-cell activation in acute and chronic chikungunya infection.
المؤلفون: Dias CNS; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Gois BM; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Lima VS; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Guerra-Gomes IC; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Araújo JMG; Molecular Biology of Cancer and Infectious Diseases Laboratory of Post-Graduation Programme on Parasite Biology, Federal University of Rio Grande do Norte, Natal, Brazil., Gomes JAS; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Araújo DAM; Department of Biotechnology, Federal University of Paraiba, João Pessoa, Brazil., Medeiros IA; Research Institute for Drugs and Medicines, Federal University of Paraíba, João Pessoa, Brazil., Azevedo FLAA; Research Institute for Drugs and Medicines, Federal University of Paraíba, João Pessoa, Brazil., Veras RC; Research Institute for Drugs and Medicines, Federal University of Paraíba, João Pessoa, Brazil., Janebro DI; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Amaral IPGD; Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., Keesen TSL; Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology of Federal University of Paraíba, João Pessoa, Paraíba, Brazil.; Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
المصدر: Immunology [Immunology] 2018 Dec; Vol. 155 (4), pp. 499-504. Date of Electronic Publication: 2018 Sep 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: CD8-Positive T-Lymphocytes/*immunology , Chikungunya Fever/*immunology , Chikungunya virus/*immunology , Cytokines/*biosynthesis , Lymphocyte Activation/*immunology, Antigens, CD/biosynthesis ; Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/biosynthesis ; Antigens, Differentiation, T-Lymphocyte/immunology ; Chikungunya Fever/pathology ; Chikungunya Fever/virology ; Cytokines/immunology ; Cytotoxicity, Immunologic/immunology ; Fas Ligand Protein/biosynthesis ; Fas Ligand Protein/immunology ; Granzymes/biosynthesis ; Granzymes/immunology ; Humans ; Interleukin-10/biosynthesis ; Interleukin-10/immunology ; Interleukin-17/biosynthesis ; Interleukin-17/immunology ; Lectins, C-Type/biosynthesis ; Lectins, C-Type/immunology ; Lysosomal-Associated Membrane Protein 1/biosynthesis ; Lysosomal-Associated Membrane Protein 1/immunology ; Perforin/biosynthesis ; Perforin/immunology ; fas Receptor/biosynthesis ; fas Receptor/immunology
مستخلص: There is a need for more detailed elucidation of T-cell immunity in chikungunya infection. CD8 T cells are one of main actors against viruses. Here, we analysed CD8 + T lymphocytes from patients in the acute and chronic phases of chikungunya disease (CHIKD). Our results demonstrate that CD8 + T cells expressed higher ex vivo granzyme B, perforin and CD107A expression in patients in the acute phase of CHIKD compared with healthy individuals and higher ex vivo expression of CD69, interleukin-17A, interleukin-10 and CD95 ligand, and co-expression of CD95/CD95 ligand. These results elucidate the importance of these lymphocytes, demonstrating immune mechanisms mediated in human chikungunya infection.
(© 2018 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: CD8 T-cell; activation; chikungunya infection; cytokines; human
المشرفين على المادة: 0 (Antigens, CD)
0 (Antigens, Differentiation, T-Lymphocyte)
0 (CD69 antigen)
0 (Cytokines)
0 (FAS protein, human)
0 (Fas Ligand Protein)
0 (IL10 protein, human)
0 (IL17A protein, human)
0 (Interleukin-17)
0 (Lectins, C-Type)
0 (Lysosomal-Associated Membrane Protein 1)
0 (fas Receptor)
126465-35-8 (Perforin)
130068-27-8 (Interleukin-10)
EC 3.4.21.- (Granzymes)
تواريخ الأحداث: Date Created: 20180813 Date Completed: 20190228 Latest Revision: 20191201
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6231013
DOI: 10.1111/imm.12992
PMID: 30099739
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2567
DOI:10.1111/imm.12992