دورية أكاديمية
أعرض في EDS

The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies.

التفاصيل البيبلوغرافية
العنوان: The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies.
المؤلفون: Ejiofor OS; Department of Pediatrics, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra State, Nigeria., Ajunwa OM; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Agulu, Nnamdi Azikiwe University, Anambra State, Nigeria., Ezeudu CE; Department of Pediatrics, College of Health Sciences, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria., Emechebe GO; Department of Pediatrics, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra State, Nigeria., Okeke KN; Department of Pediatrics, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra State, Nigeria., Ifezulike CC; Department of Pediatrics, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra State, Nigeria., Ekejindu IM; Department of Medical Laboratory Science, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria., Okoyeh JN; Department of Clinical Laboratory Science, School of Health Sciences, Winston-Salem State University, Winston-Salem, NC, USA., Osuala EO; Department of Nursing Sciences, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria., Oli AN; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Agulu, Nnamdi Azikiwe University, Anambra State, Nigeria.
المصدر: Journal of pathogens [J Pathog] 2018 Jul 02; Vol. 2018, pp. 4801247. Date of Electronic Publication: 2018 Jul 02 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101571433 Publication Model: eCollection Cited Medium: Print ISSN: 2090-3057 (Print) Linking ISSN: 20903057 NLM ISO Abbreviation: J Pathog Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Cairo : Hindawi Publishing Corporation
Original Publication: Cairo : SAGE-Hindawi Access to Research
مستخلص: Background: Neonatal infection refers to the infection of the newborn during the first twenty-eight days of life. It is one of the causes of infant morbidity and mortality worldwide. The aim of the study is to determine the relative contribution of the different pathogens to the overall disease burden. It will also determine the mechanisms of virulence of these pathogens that cause neonatal infections at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka.
Methods: Biological samples were collected from 30 neonates admitted at the special care baby unit (SCBU) of COOUTH and cultured using selective media and nutrient agar. The isolates were identified using microbiological and biochemical tests. The antibiogram study was determined using Kirby-Bauer disc diffusion method on Mueller Hinton Agar. Several methods previously reported in literature were used for the characterization of the virulence factors.
Results: From the 30 blood samples collected, Pseudomonas spp. (19.7%), Escherichia coli (23%), Salmonella spp. (24.6%), and Staphylococcus aureus (32.8%) were isolated. Male to female ratio of study population was 1.5: 1. The isolates were 100 % resistant to ticarcillin, cephalothin, ceftazidime, and cefuroxime but appreciably susceptible to only levofloxacin (88.85%). They were moderately susceptible to ceftriaxone/sulbactam (39.05%) and azithromycin (26.46%). Common virulence factors identified among the isolates (up to 90 %) were hemolysin, biofilm formation, and acid resistance. Less common virulence factors were proteases (50 %), deoxyribonucleases (50 %), enterotoxins (63%), and lipopolysaccharide (70%). The virulence factors were found mostly among the S. aureus isolates.
Conclusions: Pseudomonas spp., Escherichia coli , Salmonella spp., and Staphylococcus aureus were implicated in neonatal infections in the center and most of them were resistant to conventional antibiotics. The organisms showed marked virulence and multidrug resistance properties. Levofloxacin, a fluoroquinolone, had superior activity on the isolates compared to other antibiotics used in the study.
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تواريخ الأحداث: Date Created: 20180817 Latest Revision: 20240329
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC6077539
DOI: 10.1155/2018/4801247
PMID: 30112215
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-3057
DOI:10.1155/2018/4801247