دورية أكاديمية
Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience.
| العنوان: | Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience. |
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| المؤلفون: | Lokesh KN; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Anand A; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Lakshmaiah KC; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Babu KG; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Lokanatha D; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Jacob LA; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Babu MCS; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Rudresha AH; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Rajeev LK; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Saldanha SC; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Giri GV; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Panwar D; Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Koppaka D; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India., Patidar R; Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India. |
| المصدر: | South Asian journal of cancer [South Asian J Cancer] 2018 Jul-Sep; Vol. 7 (3), pp. 207-209. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Medical and Scientific Publishers Pvt. Ltd Country of Publication: India NLM ID: 101618774 Publication Model: Print Cited Medium: Print ISSN: 2278-330X (Print) Linking ISSN: 2278330X NLM ISO Abbreviation: South Asian J Cancer Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : UP, India : Thieme Medical and Scientific Publishers Pvt. Ltd. Original Publication: Mumbai : Medknow Publications and Media Pvt. Ltd., [2012]- |
| مستخلص: | Background: Neuroendocrine carcinoma (NEC) is a rare tumor arising from the diffuse neuroendocrine system. Most of these present in the advanced stage and palliative chemotherapy remains the only option. The prognosis remains poor with the standard chemotherapy regimen of platinum and etoposide (EP) providing modest survival benefit. Methods: The study was done for 3 years at a tertiary cancer center in South India. Patients with a diagnosis of metastatic NEC were analyzed for clinical and pathological characteristics. The treatment outcomes and prognostic factors were evaluated using appropriate statistical test. Results: A total of 114 patients of metastatic NEC satisfied the inclusion criteria and were analyzed. Gastrointestinal including hepatobiliary tract (33%) was the most common site of primary disease followed by lung (26%), genitourinary (15%), head and neck (14%), and unknown primary (9%). On analysis of pattern of metastasis, liver (65%) was the most common site followed by bone (54%) and lung (42%). The median overall survival was 11 months with a statistically significant difference between pulmonary and extrapulmonary disease (8 vs. 13 months; P = 0.003). Ki67% value was strongly associated with prognosis (hazard ratio 0.517, 95% confidence interval; 0.318-0.840, P = 0.008) whereas age, sex, and lactate dehydrogenase level did not show any relation with survival. Conclusion: The outcome of advanced NEC with standard chemotherapy remains poor. Larger studies with other therapeutic and novel agents are warranted to improve the treatment outcomes. Competing Interests: There are no conflicts of interest. |
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| فهرسة مساهمة: | Keywords: Ki67; neuroendocrine carcinoma; survival |
| تواريخ الأحداث: | Date Created: 20180817 Latest Revision: 20220318 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6069343 |
| DOI: | 10.4103/sajc.sajc_176_17 |
| PMID: | 30112343 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2278-330X |
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| DOI: | 10.4103/sajc.sajc_176_17 |