دورية أكاديمية
Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps.
العنوان: | Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps. |
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المؤلفون: | Berry KN; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Immunology Program, Washington University School of Medicine, St. Louis 63110, Missouri.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis 63110, Missouri., Kober DL; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Microbiology Program, Washington University School of Medicine, St. Louis 63110, Missouri., Su A; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri., Brett TJ; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis 63110, Missouri. |
المصدر: | BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2018 Oct; Vol. 40 (10), pp. e1800086. Date of Electronic Publication: 2018 Aug 16. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878 (Electronic) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005->: Hoboken, N.J. : Wiley Original Publication: Cambridge, UK : Published for the ICSU Press by Cambridge University Press, c1984- |
مواضيع طبية MeSH: | Antigens, CD/*physiology , Host-Pathogen Interactions/*physiology , Respiratory Tract Infections/*virology, Antigens, CD/chemistry ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/chemistry ; GPI-Linked Proteins/physiology ; Humans ; Molecular Targeted Therapy/methods ; Signal Transduction ; Virion ; Virus Diseases/immunology ; Virus Release ; Virus Replication/drug effects |
مستخلص: | Recent findings regarding the cellular biology and immunology of BST-2 (also known as tetherin) indicate that its function could be exploited as a universal replication inhibitor of enveloped respiratory viruses (e.g., influenza, respiratory syncytial virus, etc.). BST-2 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST-2 anti-viral function against respiratory viruses, how these viruses construct countermeasures to antagonize BST-2, and how BST-2 function might be targeted to develop therapies to treat respiratory virus infections. The authors address the current gaps in knowledge, including the need for mechanistic understanding of BST-2 antagonism by respiratory viruses, that should be bridged to achieve that goal. (© 2018 WILEY Periodicals, Inc.) |
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معلومات مُعتمدة: | R01 HL119813 United States HL NHLBI NIH HHS; T32 HL007317 United States HL NHLBI NIH HHS; T32 GM007200 United States GM NIGMS NIH HHS; F30 HL140783 United States HL NHLBI NIH HHS; T32 GM007067 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: antiviral; influenza; innate immunity; interferon; respiratory infections; respiratory viruses |
المشرفين على المادة: | 0 (Antigens, CD) 0 (BST2 protein, human) 0 (GPI-Linked Proteins) |
تواريخ الأحداث: | Date Created: 20180817 Date Completed: 20190625 Latest Revision: 20240402 |
رمز التحديث: | 20240402 |
مُعرف محوري في PubMed: | PMC6371793 |
DOI: | 10.1002/bies.201800086 |
PMID: | 30113067 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-1878 |
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DOI: | 10.1002/bies.201800086 |