دورية أكاديمية
أعرض في EDS

Structural Brain Connectivity in Childhood Disruptive Behavior Problems: A Multidimensional Approach.

التفاصيل البيبلوغرافية
العنوان: Structural Brain Connectivity in Childhood Disruptive Behavior Problems: A Multidimensional Approach.
المؤلفون: Bolhuis K; Department of Child and Adolescent Psychiatry; Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands., Muetzel RL; Department of Child and Adolescent Psychiatry; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Stringaris A; Mood Brain & Development Unit, Emotion and Development Branch, National Institute of Mental Health, Bethesda, Maryland., Hudziak JJ; Department of Psychiatry, Vermont Center for Children, Youth and Families, University of Vermont, Burlington, Vermont., Jaddoe VWV; Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Hillegers MHJ; Department of Child and Adolescent Psychiatry; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., White T; Department of Child and Adolescent Psychiatry; Department of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Kushner SA; Department of Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands., Tiemeier H; Department of Child and Adolescent Psychiatry; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: h.tiemeier@erasmusmc.nl.
المصدر: Biological psychiatry [Biol Psychiatry] 2019 Feb 15; Vol. 85 (4), pp. 336-344. Date of Electronic Publication: 2018 Aug 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Aggression* , Problem Behavior*, Frontal Lobe/*anatomy & histology , Juvenile Delinquency/*statistics & numerical data , Temporal Lobe/*anatomy & histology , White Matter/*anatomy & histology, Anisotropy ; Child ; Cross-Sectional Studies ; Diffusion Tensor Imaging ; Female ; Humans ; Intelligence Tests ; Irritable Mood ; Male ; Neural Pathways/anatomy & histology ; Neuroimaging
مستخلص: Background: Studies of white matter connectivity in children with disruptive behavior have yielded inconsistent results, possibly owing to the trait's heterogeneity, which comprises diverse symptoms like physical aggression, irritability, and delinquency. This study examined associations of global and specific white matter connectivity with childhood disruptive behavior problems, while accounting for their complex multidimensionality.
Methods: In a large cross-sectional population-based study of 10-year-old preadolescents (n = 2567), we assessed four previously described empirically derived dimensions of disruptive behavior problems using the Child Behavior Checklist: physical aggression, irritability, disobedient behavior, and delinquent behavior. Global and specific white matter microstructure was assessed by diffusion tensor imaging.
Results: Global fractional anisotropy and mean diffusivity were not associated with broad measures of disruptive behavior, e.g., Child Behavior Checklist externalizing problems scale. Global fractional anisotropy was negatively associated with delinquent behavior (β = -.123, p false discovery rate adjusted  = .028) and global mean diffusivity was positively associated with delinquent behavior (β = .205, p false discovery rate adjusted < 0.001), suggesting reduced white matter microstructure in preadolescents with higher levels of delinquent behavior. Lower white matter microstructure in the inferior longitudinal fasciculus, superior longitudinal fasciculus, cingulum, and uncinate underlie these associations. Global white matter microstructure was not associated with physical aggression, irritability, or disobedient behavior.
Conclusions: Delinquent behavior, a severe manifestation of childhood disruptive behavior, was associated with lower white matter microstructure in tracts connecting frontal and temporal lobes. These brain regions are involved in decision making, reward processing, and emotion regulation. This study demonstrated that incorporating the multidimensional nature of childhood disruptive behavior traits shows promise in advancing the search for elucidating neurobiological correlates of disruptive behavior.
(Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Cerebral white matter; Conduct problems; Delinquency; Diffusion tensor imaging; Disruptive behavior disorder; Irritability
تواريخ الأحداث: Date Created: 20180819 Date Completed: 20200131 Latest Revision: 20200131
رمز التحديث: 20240513
DOI: 10.1016/j.biopsych.2018.07.005
PMID: 30119874
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2402
DOI:10.1016/j.biopsych.2018.07.005