دورية أكاديمية
أعرض في EDS

Opportunities for Host-targeted Therapies for Malaria.

التفاصيل البيبلوغرافية
العنوان: Opportunities for Host-targeted Therapies for Malaria.
المؤلفون: Glennon EKK; Center for Infectious Disease Research, 307 Westlake Ave N Suite 500, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Harris Hydraulics Laboratory, Box 357965, Seattle, WA 98195, USA; These authors made an equal contribution., Dankwa S; Center for Infectious Disease Research, 307 Westlake Ave N Suite 500, Seattle, WA 98109, USA; These authors made an equal contribution., Smith JD; Center for Infectious Disease Research, 307 Westlake Ave N Suite 500, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Harris Hydraulics Laboratory, Box 357965, Seattle, WA 98195, USA., Kaushansky A; Center for Infectious Disease Research, 307 Westlake Ave N Suite 500, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Harris Hydraulics Laboratory, Box 357965, Seattle, WA 98195, USA. Electronic address: alexis.kaushansky@cidresearch.org.
المصدر: Trends in parasitology [Trends Parasitol] 2018 Oct; Vol. 34 (10), pp. 843-860. Date of Electronic Publication: 2018 Aug 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 100966034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-5007 (Electronic) Linking ISSN: 14714922 NLM ISO Abbreviation: Trends Parasitol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Elsevier Science, c2001-
مواضيع طبية MeSH: Drug Delivery Systems*, Antimalarials/*immunology, Antimalarials/pharmacology ; Host-Parasite Interactions/drug effects ; Humans ; Immunologic Factors/pharmacology
مستخلص: Despite the recent successes of artemisinin-based antimalarial drugs, many still die from severe malaria, and eradication efforts are hindered by the limited drugs currently available to target transmissible gametocyte parasites and liver-resident dormant Plasmodium vivax hypnozoites. Host-targeted therapy is a new direction for infectious disease drug development and aims to interfere with host molecules, pathways, or networks that are required for infection or that contribute to disease. Recent advances in our understanding of host pathways involved in parasite development and pathogenic mechanisms in severe malaria could facilitate the development of host-targeted interventions against Plasmodium infection and malaria disease. This review discusses new opportunities for host-targeted therapeutics for malaria and the potential to harness drug polypharmacology to simultaneously target multiple host pathways using a single drug intervention.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 GM101183 United States GM NIGMS NIH HHS; R01 HL130488 United States HL NHLBI NIH HHS; T32 AI007509 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: cerebral malaria; drug discovery; host–parasite interactions; liver; malaria; polyphamacology
المشرفين على المادة: 0 (Antimalarials)
0 (Immunologic Factors)
تواريخ الأحداث: Date Created: 20180821 Date Completed: 20190116 Latest Revision: 20230928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6168423
DOI: 10.1016/j.pt.2018.07.011
PMID: 30122551
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-5007
DOI:10.1016/j.pt.2018.07.011