دورية أكاديمية
أعرض في EDS

Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.

التفاصيل البيبلوغرافية
العنوان: Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.
المؤلفون: Boughey JC; 1Department of Surgery, Mayo Clinic, Rochester, MN USA., Alvarado MD; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Lancaster RB; 3Department of Surgery, University of Alabama at Birmingham, Birmingham, AL USA., Fraser Symmans W; 4Department of Pathology, MD Anderson Cancer Center, Houston, TX USA., Mukhtar R; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Wong JM; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Ewing CA; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Potter DA; 5Department of Medicine, University of Minnesota, Minneapolis, MN USA., Tuttle TM; 6Department of Surgery, University of Minnesota, Minneapolis, MN USA., Hieken TJ; 1Department of Surgery, Mayo Clinic, Rochester, MN USA., Carter JM; 7Department of Pathology, Mayo Clinic, Rochester, MN USA., Jakub JW; 1Department of Surgery, Mayo Clinic, Rochester, MN USA., Kaplan HG; 8Swedish, Swedish Cancer Institute, Seattle, WA USA., Buchanan CL; 8Swedish, Swedish Cancer Institute, Seattle, WA USA., Jaskowiak NT; 9Department of Surgery, University of Chicago, Chicago, IL USA., Sattar HA; 10Department of Pathology, University of Chicago, Chicago, IL USA., Mueller J; 10Department of Pathology, University of Chicago, Chicago, IL USA., Nanda R; 11Department of Hematology and Oncology, University of Chicago, Chicago, IL USA., Isaacs CJ; 12Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC USA., Pohlmann PR; 12Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC USA., Lynce F; 12Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC USA., Tousimis EA; 12Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC USA., Zeck JC; 12Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC USA., Lee MC; 13Moffitt Cancer Center, Tampa, FL USA., Lang JE; 14University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA USA., Mhawech-Fauceglia P; 14University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA USA., Rao R; 15Columbia University Medical Center, New York, NY USA., Taback B; 15Columbia University Medical Center, New York, NY USA., Chen M; 15Columbia University Medical Center, New York, NY USA., Kalinsky KM; 15Columbia University Medical Center, New York, NY USA., Hibshoosh H; 15Columbia University Medical Center, New York, NY USA., Killelea B; 16Department of Surgery and Department of Medical Oncology, Yale University, New Haven, CT USA., Sanft T; 16Department of Surgery and Department of Medical Oncology, Yale University, New Haven, CT USA., Hirst GL; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Asare S; Quantum Leap Health Care Collaborative, San Francisco, CA USA., Matthews JB; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA., Perlmutter J; Patient Representative, Ann Arbor, Michigan USA., Esserman LJ; 2UCSF Heller Diller Family Comprehensive Cancer Center, San Francisco, CA USA.
مؤلفون مشاركون: and I-SPY 2 Investigators
المصدر: NPJ breast cancer [NPJ Breast Cancer] 2018 Aug 17; Vol. 4, pp. 26. Date of Electronic Publication: 2018 Aug 17 (Print Publication: 2018).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: eCollection Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Breast Cancer Research Foundation : Nature Publishing Group, [2015]-
مستخلص: Advances in the surgical management of the axilla in patients treated with neoadjuvant chemotherapy, especially those with node positive disease at diagnosis, have led to changes in practice and more judicious use of axillary lymph node dissection that may minimize morbidity from surgery. However, there is still significant confusion about how to optimally manage the axilla, resulting in variation among practices. From the viewpoint of drug development, assessment of response to neoadjuvant chemotherapy remains paramount and appropriate assessment of residual disease-the primary endpoint of many drug therapy trials in the neoadjuvant setting-is critical. Therefore decreasing the variability, especially in a multicenter clinical trial setting, and establishing a minimum standard to ensure consistency in clinical trial data, without mandating axillary lymph node dissection, for all patients is necessary. The key elements which include proper staging and identification of nodal involvement at diagnosis, and appropriately targeted management of the axilla at the time of surgical resection are presented. The following protocols have been adopted as standard procedure by the I-SPY2 trial for management of axilla in patients with node positive disease, and present a framework for prospective clinical trials and practice.
Competing Interests: The authors declare no competing interests.
التعليقات: Erratum in: NPJ Breast Cancer. 2019 Jan 2;5:2. (PMID: 30675512)
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معلومات مُعتمدة: U01 CA225427 United States CA NCI NIH HHS
فهرسة مساهمة: Investigator: AJ Chien; A Forero-Torres; D Yee; ED Ellis; HS Han; J Lu; AM Wallace; KS Albain; AD Elias; AS Clark; K Kemmer
تواريخ الأحداث: Date Created: 20180823 Latest Revision: 20200928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6098077
DOI: 10.1038/s41523-018-0074-6
PMID: 30131975
قاعدة البيانات: MEDLINE
الوصف
تدمد:2374-4677
DOI:10.1038/s41523-018-0074-6