دورية أكاديمية
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Resistance training and caloric restriction prevent systolic blood pressure rise by improving the nitric oxide effect on smooth muscle and morphological changes in the aorta of ovariectomized rats.

التفاصيل البيبلوغرافية
العنوان: Resistance training and caloric restriction prevent systolic blood pressure rise by improving the nitric oxide effect on smooth muscle and morphological changes in the aorta of ovariectomized rats.
المؤلفون: Lino ADS; Laboratory of Exercise Physiology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program in Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Vianna D; Laboratory of Nutritional Biochemistry, Department of Food and Experimental Nutrition, University of São Paulo - USP, São Paulo, Brazil., Oishi JC; Laboratory of Pharmacology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program of Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Souza MVC; Physical Education Course, Department of Sports Science, Post-Graduate Program in Physical Education, Federal University of Triângulo Mineiro, Uberaba, Brazil., Ruffoni LD; Laboratory of Neuroendocrinology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program of Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Marin CT; Laboratory of Exercise Physiology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program in Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., de Avó LRDS; Medical Department, Center of Biological and Health Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Perez SEA; Laboratory of Exercise Physiology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program in Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Rodrigues GJ; Laboratory of Pharmacology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program of Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil., Tirapegui J; Laboratory of Nutritional Biochemistry, Department of Food and Experimental Nutrition, University of São Paulo - USP, São Paulo, Brazil., Shiguemoto GE; Laboratory of Exercise Physiology, Department of Physiological Sciences, Center of Biological and Health Sciences, Interinstitutional Post-Graduate Program in Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, Brazil.
المصدر: PloS one [PLoS One] 2018 Aug 22; Vol. 13 (8), pp. e0201843. Date of Electronic Publication: 2018 Aug 22 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Caloric Restriction* , Resistance Training*, Aorta/*pathology , Blood Pressure/*physiology , Estrogens/*deficiency , Muscle, Smooth/*metabolism, Animals ; Aorta/metabolism ; Collagen/metabolism ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Female ; Heart Rate/physiology ; Matrix Metalloproteinase 2/metabolism ; Muscle, Smooth/pathology ; Nitric Oxide/metabolism ; Ovariectomy ; Random Allocation ; Rats, Sprague-Dawley ; Sedentary Behavior
مستخلص: In this study, we investigated the effects of resistance training (RT), caloric restriction (CR), and the association of both interventions in aortic vascular reactivity and morphological alterations, matrix metalloproteinase-2 (MMP-2) activity, insulin resistance and systolic blood pressure (SBP) in ovariectomized rats. Fifty female Holtzman rats were subjected to ovariectomy and Sham surgery and distributed into the following groups: Sham-sedentary, ovariectomized-sedentary, ovariectomized-resistance training, ovariectomized-caloric restriction, and ovariectomized-resistance training and caloric restriction groups. RT and 30% CR protocols were performed for 13 weeks. Analyses were conducted to evaluate the following: acetylcholine and sodium nitroprusside-induced relaxation of aortic rings, MMP-2 activity, insulin tolerance test, highlighting of the aorta wall cross-sectional area by hematoxylin-eosin stain, aorta vessel remodeling and SBP. We observed that ovariectomy decreased the potency of dependent and independent endothelium relaxation and MMP-2 activity, prevented insulin resistance, promoted aorta vessel remodeling in the cross-sectional area, and promoted the media-to-lumen ratio, the collagen content, and the alteration of the structure and elastic fibers of the vessel. The effects of the ovariectomy could contribute to SBP increases. However, the association of exercise and diet improved the relaxation potency in dependent and independent endothelium relaxation, elevated MMP-2 activity, ameliorate insulin sensitivity, increased the aorta cross-sectional area and media-to-lumen ratio, decreased collagen content and promoted histological parameters of the aorta vessel wall, preventing the increase of SBP.
Conclusion: Our study revealed that the RT and CR separately, and even associatively, improved vascular function, activated MMP-2, and produced a beneficial hypertrophic remodeling, preventing the elevation of SBP in ovariectomized rats.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Estrogens)
31C4KY9ESH (Nitric Oxide)
9007-34-5 (Collagen)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
EC 3.4.24.24 (Mmp2 protein, rat)
تواريخ الأحداث: Date Created: 20180823 Date Completed: 20190204 Latest Revision: 20190215
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6104970
DOI: 10.1371/journal.pone.0201843
PMID: 30133537
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0201843