دورية أكاديمية
Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+ T cells activation.
| العنوان: | Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+ T cells activation. |
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| المؤلفون: | Miyagi MYS; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Latancia MT; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil; Instituto Sírio-Libanês de Ensino e Pesquisa, Hospital Sírio-Libanês, SP, Brazil., Testagrossa LA; Clinical Pathology Laboratory, Hospital Sírio-Libanês, SP, Brazil., Andrade-Oliveira V; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Pereira WO; School of Medicine, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, SP, Brazil., Hiyane MI; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Enjiu LM; Laboratory of Lipid Metabolism, Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Pisciottano M; Laboratory of Lipid Metabolism, Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Seelaender MCL; Laboratory of Lipid Metabolism, Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil., Camara NOS; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil; Laboratory of Renal Pathology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Amano MT; Laboratory of Immunobiology of Transplants, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil; Instituto Sírio-Libanês de Ensino e Pesquisa, Hospital Sírio-Libanês, SP, Brazil. Electronic address: marianeamano.usp@gmail.com. |
| المصدر: | Molecular immunology [Mol Immunol] 2018 Sep; Vol. 101, pp. 507-513. Date of Electronic Publication: 2018 Aug 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Physical Conditioning, Animal*, Acute Kidney Injury/*chemically induced , Acute Kidney Injury/*immunology , CD4-Positive T-Lymphocytes/*immunology , Cisplatin/*adverse effects , Lymphocyte Activation/*immunology, Acute Kidney Injury/prevention & control ; Animals ; Cytokines/biosynthesis ; Lymph Nodes/pathology ; Male ; Mice, Inbred C57BL ; Phenotype ; Spleen/pathology |
| مستخلص: | Cisplatin is a chemotherapy used to treat different types of cancer, such as testicular, bladder and head and neck. Physical exercise has been shown to improve cancer therapy and recently, it was demonstrated to be able to diminish side effects such as acute kidney injury (AKI), a common side effect in cisplatin treatment. In both cases, the modulation of inflammatory cytokines seems to be one of the mechanisms, but little is known about the immune cells in this process. Here, we investigated the role of CD4 + T cells in the AKI protection by physical exercise. We subjected C57Bl6 mice to long-term physical exercise (EX) before cisplatin treatment. Sedentary groups were used as control (CT). We confirmed that physical exercise decreased AKI by evaluating creatinine and Kim-1 levels, in the serum and kidney respectively. Analyzing the organs weight, we noticed a decrease in sedentary (CIS) and exercised (CIS-EX) cisplatin treated groups. Epididymal and brown adipose tissue weight were decreased in cisplatin treated subjects in comparison to untreated groups, as well as liver and spleen. We then investigated the profile of CD4 + T cells in the spleen and we observed increased levels of Tregs and CD4+CD25+ cells in CIS group, while CIS-EX presented similar amounts as control groups. Analyzing the kidney lymph nodes, we noticed a decrease of CD4+ cells in both CIS and CIS-EX group. However, a more activated phenotype (CD69+ and CD25+) was observed in CIS groups in comparison to CIS-EX group, as well as the presence of Tregs. We then investigated the production of cytokines by these cells and no difference among the groups was observed in cytokines production in splenic CD4 + T cells. However, a clear increase in TNF and IL-10 production was observed in CD4 + T cells from lymph nodes, while CIS-EX group presented similar levels as the control groups. We confirmed that physical exercise was able to diminish cisplatin-induced AKI with concomitant decrease in CD4 + T cell activation. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cisplatin; Cytokines; Exercise; Nephrotoxicity; T cells |
| المشرفين على المادة: | 0 (Cytokines) Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 20180826 Date Completed: 20190327 Latest Revision: 20190327 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.molimm.2018.08.014 |
| PMID: | 30144701 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-9142 |
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| DOI: | 10.1016/j.molimm.2018.08.014 |