دورية أكاديمية
أعرض في EDS

Nucleus of the Solitary Tract Serotonin 5-HT 2C Receptors Modulate Food Intake.

التفاصيل البيبلوغرافية
العنوان: Nucleus of the Solitary Tract Serotonin 5-HT 2C Receptors Modulate Food Intake.
المؤلفون: D'Agostino G; Rowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: giuseppe.dagostino@abdn.ac.uk., Lyons D; Rowett Institute, University of Aberdeen, Aberdeen, UK., Cristiano C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Lettieri M; Rowett Institute, University of Aberdeen, Aberdeen, UK., Olarte-Sanchez C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Burke LK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Greenwald-Yarnell M; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Cansell C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Doslikova B; Department of Pharmacology, University of Cambridge, Cambridge, UK., Georgescu T; Rowett Institute, University of Aberdeen, Aberdeen, UK., Martinez de Morentin PB; Rowett Institute, University of Aberdeen, Aberdeen, UK., Myers MG Jr; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Rochford JJ; Rowett Institute, University of Aberdeen, Aberdeen, UK., Heisler LK; Rowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: lora.heisler@abdn.ac.uk.
المصدر: Cell metabolism [Cell Metab] 2018 Oct 02; Vol. 28 (4), pp. 619-630.e5. Date of Electronic Publication: 2018 Aug 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press, c2005-
مواضيع طبية MeSH: Appetite Depressants/*therapeutic use , Benzazepines/*therapeutic use , Eating/*physiology , Obesity/*drug therapy , Serotonin 5-HT2 Receptor Agonists/*therapeutic use , Solitary Nucleus/*metabolism, Analysis of Variance ; Animals ; Appetite Depressants/metabolism ; Appetite Regulation/drug effects ; Arcuate Nucleus of Hypothalamus/cytology ; Benzazepines/metabolism ; Cell Line, Tumor ; Feeding Behavior/physiology ; Male ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptor, Serotonin, 5-HT2C/metabolism ; Serotonin 5-HT2 Receptor Agonists/metabolism ; Statistics, Nonparametric ; Transfection
مستخلص: To meet the challenge to human health posed by obesity, a better understanding of the regulation of feeding is essential. Medications targeting 5-hydroxytryptamine (5-HT; serotonin) 2C receptors (htr2c; 5-HT 2C R) improve obesity. Here we probed the functional significance of 5-HT 2C Rs specifically within the brainstem nucleus of the solitary tract (5-HT 2C R NTS ) in feeding behavior. Selective activation of 5-HT 2C R NTS decreased feeding and was sufficient to mediate acute food intake reductions elicited by the 5-HT 2C R agonist obesity medication lorcaserin. Similar to pro-opiomelanocortin neurons expressed within the hypothalamic arcuate nucleus (POMC ARC ), a subset of POMC NTS neurons co-expressed 5-HT 2C Rs and were activated by 5-HT 2C R agonists. Knockdown of POMC NTS prevented the acute appetite-suppressive effect of lorcaserin, whereas POMC ARC knockdown prevented the full anorectic effect. These data identify 5-HT 2C R NTS as a sufficient subpopulation of 5-HT 2C Rs in reducing food intake when activated and reveal that 5-HT 2C R agonist obesity medications require POMC within the NTS and ARC to reduce food intake.
(Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Cell Metab. 2018 Oct 2;28(4):533-534. (PMID: 30282043)
References: Nat Neurosci. 2004 Apr;7(4):335-6. (PMID: 15034587)
Neuroimage. 2006 Jul 1;31(3):1228-37. (PMID: 16549369)
Nat Neurosci. 2011 Mar;14(3):351-5. (PMID: 21209617)
Eur J Pharmacol. 2011 Jun 11;660(1):2-12. (PMID: 21211525)
Neuron. 2008 Nov 26;60(4):582-9. (PMID: 19038216)
Endocrinology. 2008 Mar;149(3):1323-8. (PMID: 18039773)
J Neurosci. 2005 Apr 6;25(14):3578-85. (PMID: 15814788)
Mol Metab. 2017 Oct;6(10):1092-1102. (PMID: 29031711)
J Mol Med (Berl). 2010 Dec;88(12):1195-201. (PMID: 20617297)
J Clin Invest. 2011 Apr;121(4):1424-8. (PMID: 21364278)
Neurosci Lett. 1983 Aug 8;38(3):221-5. (PMID: 6314185)
Science. 1988 Jul 29;241(4865):558-64. (PMID: 3399891)
J Neuroendocrinol. 2015 Jun;27(6):389-98. (PMID: 25925636)
Nature. 2016 Sep 1;537(7618):97-101. (PMID: 27556938)
Nature. 2015 Mar 5;519(7541):45-50. (PMID: 25707796)
Postgrad Med. 2014 Oct;126(6):7-18. (PMID: 25414931)
Science. 1976 Apr 23;192(4237):382-5. (PMID: 130678)
Endocrinology. 2014 Oct;155(10):3732-8. (PMID: 25051442)
Neuron. 2011 Aug 11;71(3):488-97. (PMID: 21835345)
Nat Biotechnol. 2015 Jan;33(1):102-6. (PMID: 25326897)
J Psychopharmacol. 2012 Jun;26(6):871-86. (PMID: 21926428)
J Clin Invest. 2012 Nov;122(11):4203-12. (PMID: 23093774)
J Neurosci. 2013 Jun 5;33(23):9800-4. (PMID: 23739976)
J Neurosci. 2013 Feb 20;33(8):3624-32. (PMID: 23426689)
Neuron. 2006 Jul 20;51(2):239-49. (PMID: 16846858)
Behav Brain Res. 2009 Jan 3;196(1):139-43. (PMID: 18762217)
J Neurosci. 2010 Nov 3;30(44):14630-4. (PMID: 21048120)
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. (PMID: 17360345)
J Neurosci Methods. 1996 May;66(1):1-11. (PMID: 8794935)
Neuropharmacology. 2009 Sep;57(3):259-67. (PMID: 19501602)
Nature. 1995 Apr 6;374(6522):542-6. (PMID: 7700379)
Int J Obes (Lond). 2009 Apr;33 Suppl 1:S11-5. (PMID: 19363500)
Elife. 2016 Mar 14;5:. (PMID: 26974347)
Science. 2014 Nov 28;346(6213):1258096. (PMID: 25430774)
Cell. 2014 Jun 5;157(6):1262-78. (PMID: 24906146)
Diabetes. 2003 Feb;52(2):315-20. (PMID: 12540602)
Endocrinology. 2008 Mar;149(3):955-61. (PMID: 18039786)
J Neurosci. 2009 Oct 28;29(43):13684-90. (PMID: 19864580)
N Engl J Med. 2010 Jul 15;363(3):245-56. (PMID: 20647200)
J Clin Invest. 2013 Dec;123(12):5061-70. (PMID: 24177424)
Mol Metab. 2016 Jan 22;5(3):245-252. (PMID: 26977396)
Science. 2002 Jul 26;297(5581):609-11. (PMID: 12142539)
معلومات مُعتمدة: MC/PC/15077 United Kingdom MRC_ Medical Research Council; WT098012 United Kingdom WT_ Wellcome Trust; P30 DK034933 United States DK NIDDK NIH HHS; MR/P009824/1 United Kingdom MRC_ Medical Research Council; BB/K001418/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/K017772/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; R01 DK056731 United States DK NIDDK NIH HHS; 105625/Z/14/Z United Kingdom WT_ Wellcome Trust; MR/L002620/1 United Kingdom MRC_ Medical Research Council; BB/N017838/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; R37 DK056731 United States DK NIDDK NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; MC_PC_15077 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: 5-HT(2C)R; food intake; lorcaserin; nucleus of the solitary tract; obesity; serotonin
المشرفين على المادة: 0 (Appetite Depressants)
0 (Benzazepines)
0 (Receptor, Serotonin, 5-HT2C)
0 (Serotonin 5-HT2 Receptor Agonists)
637E494O0Z (lorcaserin)
تواريخ الأحداث: Date Created: 20180828 Date Completed: 20191021 Latest Revision: 20220129
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6371983
DOI: 10.1016/j.cmet.2018.07.017
PMID: 30146485
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-7420
DOI:10.1016/j.cmet.2018.07.017