دورية أكاديمية
أعرض في EDS

Development, stability and in vitro delivery profile of new loratadine-loaded nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Development, stability and in vitro delivery profile of new loratadine-loaded nanoparticles.
المؤلفون: Rodriguez Amado JR; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., Prada AL; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., Duarte JL; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., Keita H; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., da Silva HR; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., Ferreira AM; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil., Sosa EH; Department of Biochemistry and Molecular Biology, Dalhousie University Halifax, Nova Scotia, Canada., Carvalho JCT; Drug Research Laboratory, Biological Science Department, Federal University of Amapá, Macapá, Brazil.; Rod. Juscelino Kubitscheck, KM 02, S/N - Jardim Marco Zero, Macapá - AP 68903-419, Brazil.
المصدر: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2017 Dec; Vol. 25 (8), pp. 1158-1168. Date of Electronic Publication: 2017 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Riyadh : Saudi Pharmaceutical Society
Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society,
مستخلص: Purpose : Loratadine is used as antihistaminic without side effects in nervous systems. This drug is a weak base and it is absorbed from the intestine. The nitrogen of the pyridine ring is protonated in the stomach affecting the oral bioavailability. The aim of this paper was obtaining, characterize and evaluate the release profiles and the stability of a gastroresistant loratadine nanosuspension. Methods : The nanosuspension was prepared by the solvent displacement evaporation method, using three different polymers (Eudragit® L 100 55, Kollicoat® MAE 100P and PEG 4000) and Polysorbate 80. Dynamic Light Scattering was used for evaluating the particle size (PS), zeta potential, and conductivity of the nanosuspension. Loratadine release profiles were evaluated in simulated gastrointestinal fluids. The shelf and accelerated stability were assessed during three months. Results : Nanosuspension particle size was 45.94 ± 0.50 nm, with a low polydispersion index (PdI, 0.300). Kollicoat® MAE 100P produced a hard and flexible coating layer. In simulated intestinal fluids, the 100 percent of loratadine was released in 40 min, while in simulated stomach fluids the release was lesser than 5%. Nanosuspension presented a good physicochemical stability showing a reduction in PS and PdI after three months (43.29 ± 0.16 and 0.250; respectively). Conclusions : A promissory loratadine nanosuspension for loratadine intestinal delivery was obtained, by using a low energy method, which is an advantage for a possible scale up for practical purpose.
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فهرسة مساهمة: Keywords: DLS; Loratadine; Nanoparticles; Nanosuspension; Simulated gastric fluids; Zeta potential
تواريخ الأحداث: Date Created: 20180901 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6111125
DOI: 10.1016/j.jsps.2017.07.008
PMID: 30166904
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-0164
DOI:10.1016/j.jsps.2017.07.008