دورية أكاديمية
أعرض في EDS

Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β 2 -adrenergic agonist response in an ischemia-reperfusion lung injury model.

التفاصيل البيبلوغرافية
العنوان: Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β 2 -adrenergic agonist response in an ischemia-reperfusion lung injury model.
المؤلفون: Richard C; Centre de recherche, Centre hospitalier de l'université de Montréal (CHUM), Canada., Shabbir W; Institute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria., Ferraro P; Centre de recherche, Centre hospitalier de l'université de Montréal (CHUM), Canada; Département de chirurgie, Université de Montréal, Montréal, Québec, Canada., Massé C; Centre de recherche, Centre hospitalier de l'université de Montréal (CHUM), Canada; Institut de recherches cliniques de Montréal (IRCM), Montréal, Quebec, Canada., Berthiaume Y; Centre de recherche, Centre hospitalier de l'université de Montréal (CHUM), Canada; Département de médecine, Université de Montréal, Montréal, Québec, Canada; Institut de recherches cliniques de Montréal (IRCM), Montréal, Quebec, Canada. Electronic address: yves.berthiaume@umontreal.ca.
المصدر: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2019 Jan; Vol. 259, pp. 104-110. Date of Electronic Publication: 2018 Aug 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2002-
مواضيع طبية MeSH: Lung Injury*/etiology , Lung Injury*/physiopathology, Pulmonary Alveoli/*physiopathology , Receptors, Adrenergic, beta-2/*therapeutic use , Reperfusion Injury/*complications, Aminophylline/pharmacology ; Animals ; Blood Pressure/drug effects ; Bronchodilator Agents/pharmacology ; Cyclic AMP/pharmacology ; Disease Models, Animal ; Dogs ; Dose-Response Relationship, Drug ; Epithelial Sodium Channels/metabolism ; Female ; Heart Rate/drug effects ; Imidazoles/therapeutic use ; Iodine Radioisotopes/pharmacokinetics ; Iodocyanopindolol/pharmacokinetics ; Male ; Propanolamines/therapeutic use ; Protein Binding/drug effects ; Pulmonary Edema/etiology ; RNA, Messenger
مستخلص: While alveolar liquid clearance (ALC) mediated by the β 2 -adrenergic receptor (β 2 -AR) plays an important role in lung edema resolution in certain models of lung injury, in more severe lung injury models, this response might disappear. Indeed, we have shown that in an ischemia-reperfusion-induced lung injury model, β 2 -agonists do not enhance ALC. The objective of this study was to determine if downregulation of the β 2 -AR could explain the lack of response to β 2 -agonists in this lung injury model. In an in vivo canine model of lung transplantation, we observed no change in β 2 -AR concentration or affinity in the injured transplanted lungs compared to the native lungs. Furthermore, we could not enhance ALC in transplanted lungs with dcAMP + aminophylline, a treatment that bypasses the β 2 -adrenergic receptor and is known to stimulate ALC in normal lungs. However, transplantation decreased αENaC expression in the lungs by 50%. We conclude that the lack of response to β 2 -agonists in ischemia-reperfusion-induced lung injury is not associated with significant downregulation of the β 2 -adrenergic receptors but is attributable to decreased expression of the ENaC channel, which is essential for sodium transport and alveolar liquid clearance in the lung.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Alveolar liquid clearance; Epithelial sodium channel (ENaC); Ischemia-reperfusion; Lung injury; Lung transplantation; β(2)-Adrenergic receptor
المشرفين على المادة: 0 (Bronchodilator Agents)
0 (Epithelial Sodium Channels)
0 (Imidazoles)
0 (Iodine Radioisotopes)
0 (Propanolamines)
0 (RNA, Messenger)
0 (Receptors, Adrenergic, beta-2)
27Y3KJK423 (Aminophylline)
46OL1UC10R (ICI 118551)
83498-72-0 (Iodocyanopindolol)
CNU8DA2K9J (CGP 20712A)
E0399OZS9N (Cyclic AMP)
GVO776611R (Iodine-125)
تواريخ الأحداث: Date Created: 20180902 Date Completed: 20190403 Latest Revision: 20190403
رمز التحديث: 20240628
DOI: 10.1016/j.resp.2018.08.006
PMID: 30171906
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1519
DOI:10.1016/j.resp.2018.08.006