دورية أكاديمية
Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors.
| العنوان: | Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors. |
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| المؤلفون: | Coffin KM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Liu J; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Warren TK; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Blancett CD; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Kuehl KA; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Nichols DK; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Bearss JJ; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Schellhase CW; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Retterer CJ; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Weidner JM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Radoshitzky SR; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Brannan JM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Cardile AP; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Dye JM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Palacios G; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Sun MG; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA., Bavari S; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA., Zeng X; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA. Electronic address: xiankun.zeng.fn@mail.mil. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2018 Sep 12; Vol. 24 (3), pp. 405-416.e3. Date of Electronic Publication: 2018 Aug 30. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Marburg Virus Disease/*virology , Marburgvirus/*physiology , Primate Diseases/*virology , Testis/*virology, Animals ; Macaca ; Male ; Marburg Virus Disease/immunology ; Marburg Virus Disease/metabolism ; Primate Diseases/immunology ; Primate Diseases/metabolism ; Sertoli Cells/metabolism ; Sertoli Cells/virology ; Survivors ; T-Lymphocytes, Regulatory/immunology ; Tight Junctions/metabolism ; Tight Junctions/virology |
| مستخلص: | Sexual transmission of filoviruses was first reported in 1968 after an outbreak of Marburg virus (MARV) disease and recently caused flare-ups of Ebola virus disease in the 2013-2016 outbreak. How filoviruses establish testicular persistence and are shed in semen remain unknown. We discovered that persistent MARV infection of seminiferous tubules, an immune-privileged site that harbors sperm production, is a relatively common event in crab-eating macaques that survived infection after antiviral treatment. Persistence triggers severe testicular damage, including spermatogenic cell depletion and inflammatory cell invasion. MARV mainly persists in Sertoli cells, leading to breakdown of the blood-testis barrier formed by inter-Sertoli cell tight junctions. This disruption is accompanied by local infiltration of immunosuppressive CD4 + Foxp3 + regulatory T cells. Our study elucidates cellular events associated with testicular persistence that may promote sexual transmission of filoviruses and suggests that targeting immunosuppression may be warranted to clear filovirus persistence in damaged immune-privileged sites. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | HHSN272200700016I United States AO NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: EBOV; Ebola virus; MARV; Marburg virus; Treg; filovirus; immunosuppression; persistent infection; testis; viral persistence |
| تواريخ الأحداث: | Date Created: 20180904 Date Completed: 20190403 Latest Revision: 20200930 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chom.2018.08.003 |
| PMID: | 30173956 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2018.08.003 |