دورية أكاديمية
Non-motor symptoms in early Parkinson's disease with different motor subtypes and their associations with quality of life.
| العنوان: | Non-motor symptoms in early Parkinson's disease with different motor subtypes and their associations with quality of life. |
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| المؤلفون: | Huang X; Department of Neurology, National Neuroscience Institute, Singapore.; Duke-NUS Graduate Medical School, Singapore., Ng SY; Department of Neurology, National Neuroscience Institute, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Chia NS; Department of Neurology, National Neuroscience Institute, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Setiawan F; Department of Neurology, National Neuroscience Institute, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Tay KY; Department of Neurology, National Neuroscience Institute, Singapore.; Duke-NUS Graduate Medical School, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Au WL; Department of Neurology, National Neuroscience Institute, Singapore.; Duke-NUS Graduate Medical School, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Tan EK; Department of Neurology, National Neuroscience Institute, Singapore.; Duke-NUS Graduate Medical School, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Tan LC; Department of Neurology, National Neuroscience Institute, Singapore.; Duke-NUS Graduate Medical School, Singapore.; Parkinson's Disease and Movement Disorders Centre, Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore, Singapore. |
| المصدر: | European journal of neurology [Eur J Neurol] 2019 Mar; Vol. 26 (3), pp. 400-406. Date of Electronic Publication: 2018 Sep 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol |
| أسماء مطبوعة: | Publication: <2014- > : Oxford : Wiley Original Publication: Oxford ; New York : Rapid Communications, [1994- |
| مواضيع طبية MeSH: | Fatigue*/etiology , Fatigue*/physiopathology , Parkinson Disease*/classification , Parkinson Disease*/complications , Parkinson Disease*/physiopathology , Quality of Life* , Sleep Wake Disorders*/etiology , Sleep Wake Disorders*/physiopathology, Aged ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged |
| مستخلص: | Background and Purpose: The aim of this study was to examine non-motor symptoms in different Parkinson's disease (PD) motor subtypes and their associations with quality of life (QoL). Methods: A total of 132 patients with early PD with comprehensive motor examinations and non-motor symptom assessments were included. Motor subtypes were classified based on Stebbins' method. Non-motor symptoms were assessed by the Non-Motor Symptom Scale (NMSS) and validated by more comprehensive instruments, including the Pittsburgh Sleep Quality Index (PSQI) and Fatigue Severity Scale (FSS). QoL was measured by the Parkinson's Disease Questionnaire-8. Results: We identified 66 patients (50%) with tremor-dominant (TD) subtype, 47 (35.6%) with postural instability and gait disorder (PIGD) subtype and 19 (14.4%) with Intermediate subtype. By comparing NMSS scores, patients with the PIGD subtype had more severe sleep impairment and fatigue (domain 2 score: 5.64 vs. 2.52, P < 0.001), urinary symptoms (domain 7 score: 6.96 vs. 3.48, P = 0.005) and overall more severe non-motor symptoms (NMSS total score: 25.89 vs. 17.27, P = 0.031), compared with patients with the TD subtype. Validation using the PSQI and FSS again suggested that patients with the PIGD subtype had independently and significantly more severe sleep impairment (PSQI score: 5.57 vs. 4.29, P = 0.020) and fatigue (FSS score: 34.81 vs. 25.85, P = 0.003) compared with patients with the TD subtype. Several non-motor symptoms had significant associations with QoL, among which sleep impairment and fatigue (P < 0.0001, partial r 2 = 0.273) explained the largest proportion of QoL variability in patients with PD. Conclusions: Patients with the PIGD subtype had more severe sleep impairment, fatigue and urinary disturbance compared with patients with the TD subtype. Sleep impairment and fatigue were the most important factors affecting QoL independent of motor subtypes. Prompt identification and treatment of these non-motor symptoms may improve patients' QoL. (© 2018 EAN.) |
| التعليقات: | Comment in: Eur J Neurol. 2019 Mar;26(3):e37. (PMID: 30724429) Comment in: Eur J Neurol. 2019 Mar;26(3):e38. (PMID: 30724431) |
| فهرسة مساهمة: | Keywords: early Parkinson's disease; fatigue; motor subtypes; non-motor symptoms; postural instability/gait difficulty; sleep impairment; tremor-dominant |
| تواريخ الأحداث: | Date Created: 20180904 Date Completed: 20190819 Latest Revision: 20190819 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/ene.13803 |
| PMID: | 30175887 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-1331 |
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| DOI: | 10.1111/ene.13803 |