دورية أكاديمية
INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL.
| العنوان: | INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL. |
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| المؤلفون: | Timofeev SA, Tokarev YS, Simakova AV, Tsarev AA, Dolgikh VV |
| المصدر: | Tsitologiia [Tsitologiia] 2016; Vol. 58 (8), pp. 594-601. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Rossiiskaia Akademiia Nauk Country of Publication: Russia (Federation) NLM ID: 0417363 Publication Model: Print Cited Medium: Print ISSN: 0041-3771 (Print) Linking ISSN: 00413771 NLM ISO Abbreviation: Tsitologiia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Rossiiskaia Akademiia Nauk Original Publication: Moskva, Akademiia nauk SSSR. |
| مواضيع طبية MeSH: | Host-Parasite Interactions*, Microsporidia/*pathogenicity, Animals ; Cell Physiological Phenomena ; Cytoplasm |
| مستخلص: | Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drives these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme dependence on the host cell, as well as sophisticated host-parasite relationships. In this review we summarize our results and recent literature data about microsporidian interactions with the host at the cellular level. The impacts of these pathogens to infected cells include induction of hypertrophy, restructuring and modification of the cytoskeleton and the vesicular transport system of the host cells. Microsporidians also able to stimulate the metabolic processes in the infected cells and inhibit their defensive reactions. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere to regulatory and signaling pathways of the host cell. |
| تواريخ الأحداث: | Date Created: 20180906 Date Completed: 20180914 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| PMID: | 30183199 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0041-3771 |
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