دورية أكاديمية
Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity.
| العنوان: | Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. |
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| المؤلفون: | Ito Y; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA., Ashenberg O; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Pyrdol J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA., Rozenblatt-Rosen O; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Hofree M; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Christian E; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Ferrari de Andrade L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA., Tay RE; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA., Teyton L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA., Regev A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA stephanie_dougan@dfci.harvard.edu.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA kai_wucherpfennig@dfci.harvard.edu.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2018 Oct 01; Vol. 215 (10), pp. 2617-2635. Date of Electronic Publication: 2018 Sep 05. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Antigen Presentation* , Autoimmunity*, Antigens, Differentiation, B-Lymphocyte/*immunology , CD4-Positive T-Lymphocytes/*immunology , Histocompatibility Antigens Class II/*immunology, Animals ; Antigens, Differentiation, B-Lymphocyte/genetics ; CD4-Positive T-Lymphocytes/cytology ; Gene Knock-In Techniques ; Histocompatibility Antigens Class II/genetics ; Mice ; Mice, Inbred NOD ; Mice, Transgenic |
| مستخلص: | A number of autoimmunity-associated MHC class II proteins interact only weakly with the invariant chain-derived class II-associated invariant chain peptide (CLIP). CLIP dissociates rapidly from I-A g7 even in the absence of DM, and this property is related to the type 1 diabetes-associated β57 polymorphism. We generated knock-in non-obese diabetic (NOD) mice with a single amino acid change in the CLIP segment of the invariant chain in order to moderately slow CLIP dissociation from I-A g7 These knock-in mice had a significantly reduced incidence of spontaneous type 1 diabetes and diminished islet infiltration by CD4 T cells, in particular T cells specific for fusion peptides generated by covalent linkage of proteolytic fragments within β cell secretory granules. Rapid CLIP dissociation enhanced the presentation of such extracellular peptides, thus bypassing the conventional MHC class II antigen-processing pathway. Autoimmunity-associated MHC class II polymorphisms therefore not only modify binding of self-peptides, but also alter the biochemistry of peptide acquisition. (© 2018 Ito et al.) |
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| معلومات مُعتمدة: | P01 AI045757 United States AI NIAID NIH HHS; T32 CA207021 United States CA NCI NIH HHS |
| سلسلة جزيئية: | PDB 1ES0 |
| المشرفين على المادة: | 0 (Antigens, Differentiation, B-Lymphocyte) 0 (Histocompatibility Antigens Class II) 0 (invariant chain) |
| تواريخ الأحداث: | Date Created: 20180907 Date Completed: 20190904 Latest Revision: 20191023 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6170167 |
| DOI: | 10.1084/jem.20180300 |
| PMID: | 30185635 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
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| DOI: | 10.1084/jem.20180300 |