دورية أكاديمية
أعرض في EDS

Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells.

التفاصيل البيبلوغرافية
العنوان: Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells.
المؤلفون: Yale AR; Department of Anatomy & Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Nourse JL; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Lee KR; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Ahmed SN; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Arulmoli J; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA., Jiang AYL; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA., McDonnell LP; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Botten GA; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA., Lee AP; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA., Monuki ES; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Demetriou M; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA., Flanagan LA; Department of Anatomy & Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: lisa.flanagan@uci.edu.
المصدر: Stem cell reports [Stem Cell Reports] 2018 Oct 09; Vol. 11 (4), pp. 869-882. Date of Electronic Publication: 2018 Sep 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2013-
مواضيع طبية MeSH: Cell Lineage* , Electrophysiological Phenomena*, Cell Membrane/*metabolism , Neural Stem Cells/*cytology , Neural Stem Cells/*metabolism , Polysaccharides/*metabolism, Acetylglucosamine/metabolism ; Animals ; Astrocytes/cytology ; Brain/cytology ; Cell Differentiation ; Cell Proliferation ; Cell Size ; Cell Survival ; Fucose/metabolism ; Gene Expression Regulation ; Glycosylation ; Mice ; N-Acetylneuraminic Acid/metabolism ; Neurogenesis ; Stem Cell Niche
مستخلص: Understanding the cellular properties controlling neural stem and progenitor cell (NSPC) fate choice will improve their therapeutic potential. The electrophysiological measure whole-cell membrane capacitance reflects fate bias in the neural lineage but the cellular properties underlying membrane capacitance are poorly understood. We tested the hypothesis that cell surface carbohydrates contribute to NSPC membrane capacitance and fate. We found NSPCs differing in fate potential express distinct patterns of glycosylation enzymes. Screening several glycosylation pathways revealed that the one forming highly branched N-glycans differs between neurogenic and astrogenic populations of cells in vitro and in vivo. Enhancing highly branched N-glycans on NSPCs significantly increases membrane capacitance and leads to the generation of more astrocytes at the expense of neurons with no effect on cell size, viability, or proliferation. These data identify the N-glycan branching pathway as a significant regulator of membrane capacitance and fate choice in the neural lineage.
(Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
References: J Biol Chem. 2006 Oct 27;281(43):32122-30. (PMID: 16940045)
Lab Chip. 2012 Jun 21;12(12):2182-9. (PMID: 22460949)
Bioelectrochemistry. 2007 May;70(2):542-50. (PMID: 17350897)
Science. 2004 Oct 1;306(5693):120-4. (PMID: 15459394)
Cancer Sci. 2008 Jul;99(7):1304-10. (PMID: 18492092)
J Biol Chem. 2003 Dec 26;278(52):52412-24. (PMID: 14561752)
Stem Cells Dev. 2013 Dec 1;22(23):3100-13. (PMID: 23829188)
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):728-32. (PMID: 8290590)
Biochem Soc Trans. 2008 Dec;36(Pt 6):1472-7. (PMID: 19021578)
Nat Rev Cancer. 2015 Sep;15(9):540-55. (PMID: 26289314)
Cell Mol Life Sci. 2001 Jul;58(8):1085-104. (PMID: 11529501)
Mol Brain. 2011 Jan 27;4:7. (PMID: 21269521)
Biochem Biophys Res Commun. 2008 May 16;369(4):1022-6. (PMID: 18331832)
Glycoconj J. 2009 Apr;26(3):367-84. (PMID: 19037724)
J Biol Chem. 1982 Oct 10;257(19):11230-4. (PMID: 7118880)
Neuron. 2000 Oct;28(1):69-80. (PMID: 11086984)
Langmuir. 2009 Apr 9;25(6):3867-75. (PMID: 19227986)
Hum Mol Genet. 2009 Jul 15;18(14):2599-608. (PMID: 19403558)
J Neurosci. 2016 Nov 23;36(47):11904-11917. (PMID: 27881777)
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6462-7. (PMID: 21464296)
Biomicrofluidics. 2014 Nov 20;8(6):064106. (PMID: 25553183)
Curr Stem Cell Rep. 2018 Jun;4(2):116-126. (PMID: 36311261)
J Neurosci. 2001 Nov 15;21(22):8854-62. (PMID: 11698597)
Biochimie. 1988 Nov;70(11):1521-33. (PMID: 2977290)
Biomicrofluidics. 2012 Aug 13;6(3):34113. (PMID: 23940503)
Brain Res. 1995 Apr 24;678(1-2):99-109. (PMID: 7620904)
Glycobiology. 2007 Mar;17(3):261-76. (PMID: 17172259)
Biochim Biophys Acta. 1994 Aug 3;1193(2):330-44. (PMID: 8054355)
Biochim Biophys Acta. 1990 Apr 23;1034(1):93-101. (PMID: 2328267)
Nature. 2014 Jul 17;511(7509):319-25. (PMID: 25030168)
Glycobiology. 2004 Apr;14(4):357-63. (PMID: 14693917)
Stem Cells. 2014 Mar;32(3):706-16. (PMID: 24105912)
Annu Rev Biochem. 2004;73:491-537. (PMID: 15189151)
Stem Cells. 2008 Mar;26(3):656-65. (PMID: 18096719)
J Neurosci Res. 2002 Jun 1;68(5):501-10. (PMID: 12111840)
Neuron. 2005 Mar 24;45(6):873-86. (PMID: 15797549)
Cell. 2007 Apr 6;129(1):123-34. (PMID: 17418791)
Dev Biol. 2001 Jan 1;229(1):15-30. (PMID: 11133151)
Stem Cell Res. 2014 Nov;13(3 Pt A):454-64. (PMID: 25460606)
PLoS One. 2011;6(9):e25458. (PMID: 21980464)
J Cell Sci. 2015 Jul 1;128(13):2213-9. (PMID: 26092931)
Chembiochem. 2017 Aug 4;18(15):1496-1501. (PMID: 28493500)
Cell Biol Int. 2002;26(7):627-33. (PMID: 12127942)
Anal Chem. 2014 Nov 4;86(21):10855-63. (PMID: 25343746)
Integr Biol (Camb). 2012 Oct;4(10):1223-36. (PMID: 22892587)
معلومات مُعتمدة: T32 NS082174 United States NS NINDS NIH HHS; UL1 TR001414 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: L-PHA; MGAT; astrocyte progenitor; biophysical; branch; dielectrophoresis; glycosylation; membrane capacitance; mouse; neuron progenitor
المشرفين على المادة: 0 (Polysaccharides)
28RYY2IV3F (Fucose)
GZP2782OP0 (N-Acetylneuraminic Acid)
V956696549 (Acetylglucosamine)
تواريخ الأحداث: Date Created: 20180911 Date Completed: 20190920 Latest Revision: 20230928
رمز التحديث: 20230928
مُعرف محوري في PubMed: PMC6178213
DOI: 10.1016/j.stemcr.2018.08.011
PMID: 30197120
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-6711
DOI:10.1016/j.stemcr.2018.08.011