دورية أكاديمية
أعرض في EDS

YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.

التفاصيل البيبلوغرافية
العنوان: YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.
المؤلفون: Morris FC; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Wells TJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Bryant JA; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Schager AE; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Sevastsyanovich YR; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Squire DJP; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Marshall J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Isom GL; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Rooke J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Maderbocus R; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Knowles TJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Overduin M; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Rossiter AE; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Cunningham AF; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Henderson IR; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom i.r.henderson@bham.ac.uk.
المصدر: Infection and immunity [Infect Immun] 2018 Oct 25; Vol. 86 (11). Date of Electronic Publication: 2018 Oct 25 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : American Society For Microbiology
Original Publication: [Bethesda, Md.] American Society for Microbiology.
مواضيع طبية MeSH: Bacterial Outer Membrane Proteins/*metabolism , Lipoproteins/*metabolism , Salmonella Infections/*microbiology , Salmonella Infections/*pathology , Salmonella typhimurium/*pathogenicity , Virulence Factors/*metabolism, Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Outer Membrane Proteins/genetics ; Cell Line ; Disease Models, Animal ; Epithelial Cells/microbiology ; Humans ; Lipoproteins/genetics ; Macrophages/microbiology ; Mice, Inbred C57BL ; Microbial Sensitivity Tests ; Mutation ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/genetics ; Salmonella typhimurium/growth & development ; Virulence ; Virulence Factors/genetics
مستخلص: Mutations in σ E -regulated lipoproteins have previously been shown to impact bacterial viability under conditions of stress and during in vivo infection. YraP is conserved across a number of Gram-negative pathogens, including Neisseria meningitidis , where the homolog is a component of the Bexsero meningococcal group B vaccine. Investigations using laboratory-adapted Escherichia coli K-12 have shown that yraP mutants have elevated sensitivity to a range of compounds, including detergents and normally ineffective antibiotics. In this study, we investigate the role of the outer membrane lipoprotein YraP in the pathogenesis of Salmonella enterica serovar Typhimurium. We show that mutations in S Typhimurium yraP result in a defective outer membrane barrier with elevated sensitivity to a range of compounds. This defect is associated with attenuated virulence in an oral infection model and during the early stages of systemic infection. We show that this attenuation is not a result of defects in lipopolysaccharide and O-antigen synthesis, changes in outer membrane protein levels, or the ability to adhere to and invade eukaryotic cell lines in vitro .
(Copyright © 2018 American Society for Microbiology.)
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معلومات مُعتمدة: MR/N023706/1 United Kingdom MRC_ Medical Research Council; United Kingdom BB_ Biotechnology and Biological Sciences Research Council
فهرسة مساهمة: Keywords: Salmonella; YraP; virulence
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Bacterial Outer Membrane Proteins)
0 (Lipoproteins)
0 (Virulence Factors)
تواريخ الأحداث: Date Created: 20180912 Date Completed: 20190412 Latest Revision: 20210109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6204713
DOI: 10.1128/IAI.00829-17
PMID: 30201701
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-5522
DOI:10.1128/IAI.00829-17