دورية أكاديمية
أعرض في EDS

Early toxicity and patient reported quality-of-life in patients receiving proton therapy for localized prostate cancer: a single institutional review of prospectively recorded outcomes.

التفاصيل البيبلوغرافية
العنوان: Early toxicity and patient reported quality-of-life in patients receiving proton therapy for localized prostate cancer: a single institutional review of prospectively recorded outcomes.
المؤلفون: Lee HJ Jr; Duke University School of Medicine, 10 Duke Medicine Circle, Durham, NC, 27710, USA., Macomber MW; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Spraker MB; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Bowen SR; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Hippe DS; Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 357115, Seattle, WA, 98195, USA., Fung A; Seattle Cancer Care Alliance Proton Therapy Center, 1570 N 115th St, Seattle, WA, 98115, USA., Russell KJ; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Laramore GE; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Rengan R; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Liao J; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Apisarnthanarax S; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA., Zeng J; Department of Radiation Oncology, University of Washington School of Medicine, 1959 NE Pacific Street, Campus, Box 356043, Seattle, WA, 98195, USA. jzeng13@uw.edu.
المصدر: Radiation oncology (London, England) [Radiat Oncol] 2018 Sep 17; Vol. 13 (1), pp. 179. Date of Electronic Publication: 2018 Sep 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Quality of Life*, Prostatic Neoplasms/*radiotherapy , Proton Therapy/*adverse effects, Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Prospective Studies ; Prostatic Neoplasms/pathology ; Proton Therapy/methods ; Regression Analysis ; Treatment Outcome
مستخلص: Background: We report prospectively captured clinical toxicity and patient reported outcomes in a single institutional cohort of patients treated for prostate cancer with proton beam therapy (PBT). This is the largest reported series of patients treated mostly with pencil beam scanning PBT.
Methods: We reviewed 231 patients treated on an IRB approved institutional registry from 2013 to 2016; final analysis included 192 patients with > 1-year of follow-up. Toxicity incidence was prospectively captured and scored using CTCAE v4.0. International Prostate Symptoms Score (IPSS), Sexual Health Inventory for Men (SHIM) score, and Expanded Prostate Cancer Index Composite (EPIC) bowel domain questionnaires were collected at each visit. Univariate Cox regression was used to explore associations of grade 2+ toxicity with clinical, treatment, and dosimetric variables.
Results: Median follow-up was 1.7 years. Grade 3 toxicity was seen in 5/192 patients. No grade 4 or 5 toxicity was seen. Patient reported quality-of-life showed no change in urinary function post-radiation by IPSS scores. Median SHIM scores declined by 3.7 points at 1-year post-treatment without further decrease beyond year 1. On univariate analysis, only younger age (HR = 0.61, p = 0.022) was associated with decreased sexual toxicity. EPIC bowel domain scores declined from 96 at baseline (median) by an average of 5.4 points at 1-year post-treatment (95% CI: 2.5-8.2 points, p < 0.001), with no further decrease over time. Bowel toxicity was mostly in the form of transient rectal bleeding and was associated with anticoagulation use (HR = 3.45, p = 0.002).
Conclusions: Grade 3 or higher toxicity was rare at 2-years after treatment with PBT for localized prostate cancer. Longer follow-up is needed to further characterize late toxicity and biochemical control.
Trial Registration: NCT, NCT01255748 . Registered 1 January 2013.
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معلومات مُعتمدة: UL1 TR002319 United States TR NCATS NIH HHS; UL1 TR002319 National Center for Advancing Translational Sciences (US)
فهرسة مساهمة: Keywords: Patient reported outcomes; Prostate cancer; Proton therapy; Quality of life
سلسلة جزيئية: ClinicalTrials.gov NCT01255748
تواريخ الأحداث: Date Created: 20180919 Date Completed: 20190314 Latest Revision: 20190314
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6142310
DOI: 10.1186/s13014-018-1127-6
PMID: 30223877
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-717X
DOI:10.1186/s13014-018-1127-6