دورية أكاديمية
أعرض في EDS

CNS-resident classical DCs play a critical role in CNS autoimmune disease.

التفاصيل البيبلوغرافية
العنوان: CNS-resident classical DCs play a critical role in CNS autoimmune disease.
المؤلفون: Giles DA; Holtom-Garrett Program in Neuroimmunology, Department of Neurology.; Graduate Program in Immunology, and.; Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, USA., Duncker PC; Holtom-Garrett Program in Neuroimmunology, Department of Neurology.; Graduate Program in Immunology, and., Wilkinson NM; Holtom-Garrett Program in Neuroimmunology, Department of Neurology., Washnock-Schmid JM; Holtom-Garrett Program in Neuroimmunology, Department of Neurology., Segal BM; Holtom-Garrett Program in Neuroimmunology, Department of Neurology.; Graduate Program in Immunology, and.; Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
المصدر: The Journal of clinical investigation [J Clin Invest] 2018 Dec 03; Vol. 128 (12), pp. 5322-5334. Date of Electronic Publication: 2018 Oct 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Antigen Presentation/*immunology , Brain/*immunology , Dendritic Cells/*immunology , Encephalomyelitis, Autoimmune, Experimental/*immunology , Spinal Cord/*immunology, Adoptive Transfer ; Animals ; Brain/pathology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/transplantation ; Cytokines/genetics ; Cytokines/immunology ; Dendritic Cells/pathology ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Myelin-Oligodendrocyte Glycoprotein/genetics ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Spinal Cord/pathology
مستخلص: Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS), induced by the adoptive transfer of myelin-reactive CD4+ T cells into naive syngeneic mice. It is widely used as a rodent model of multiple sclerosis (MS). The development of EAE lesions is initiated when transferred CD4+ T cells access the CNS and are reactivated by local antigen-presenting cells (APCs) bearing endogenous myelin peptide/MHC class II complexes. The identity of the CNS-resident, lesion-initiating APCs is widely debated. Here we demonstrate that classical dendritic cells (cDCs) normally reside in the meninges, brain, and spinal cord in the steady state. These cells are unique among candidate CNS APCs in their ability to stimulate naive, as well as effector, myelin-specific T cells to proliferate and produce proinflammatory cytokines directly ex vivo. cDCs expanded in the meninges and CNS parenchyma in association with disease progression. Selective depletion of cDCs led to a decrease in the number of myelin-primed donor T cells in the CNS and reduced the incidence of clinical EAE by half. Based on our findings, we propose that cDCs, and the factors that regulate them, be further investigated as potential therapeutic targets in MS.
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معلومات مُعتمدة: R01 NS105385 United States NS NINDS NIH HHS; R21 NS103215 United States NS NINDS NIH HHS; T32 AI007413 United States AI NIAID NIH HHS; T32 GM007863 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Antigen presenting cells; Autoimmune diseases; Autoimmunity; Multiple sclerosis; Neuroscience
المشرفين على المادة: 0 (Cytokines)
0 (Myelin-Oligodendrocyte Glycoprotein)
تواريخ الأحداث: Date Created: 20180919 Date Completed: 20190916 Latest Revision: 20190916
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6264723
DOI: 10.1172/JCI123708
PMID: 30226829
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI123708