Multimodality Screening of Hepatic Nodules in Patients With Congenital Heart Disease After Fontan Procedure: Role of Ultrasound, ARFI Elastography, CT, and MRI.

التفاصيل البيبلوغرافية
العنوان:	Multimodality Screening of Hepatic Nodules in Patients With Congenital Heart Disease After Fontan Procedure: Role of Ultrasound, ARFI Elastography, CT, and MRI.
المؤلفون:	Horvat N; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil., Rocha MS; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil., Chagas AL; 2 Hepatology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Oliveira BC; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil., Pacheco MP; 2 Hepatology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Binotto MA; 3 Cardiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Ikari NM; 3 Cardiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Paranaguá-Vezozzo DC; 2 Hepatology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Leao-Filho HM; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil., Vicentini JRT; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil., Moreira da Silva Filho MR; 4 Medical School, Universidade de São Paulo, São Paulo, Brazil., Jatene MB; 3 Cardiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Carrilho FJ; 2 Hepatology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Cerri GG; 1 Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dr. Enéas de Carvalho Aguiar, Rua Dr. Ovídio Pires de Campos, 255 Cerqueira César, São Paulo, SP 05403-900, Brazil.
المصدر:	AJR. American journal of roentgenology [AJR Am J Roentgenol] 2018 Dec; Vol. 211 (6), pp. 1212-1220. Date of Electronic Publication: 2018 Sep 24.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Roentgen Ray Society Country of Publication: United States NLM ID: 7708173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-3141 (Electronic) Linking ISSN: 0361803X NLM ISO Abbreviation: AJR Am J Roentgenol
أسماء مطبوعة:	Publication: <2004-> : Leesburg, VA : American Roentgen Ray Society Original Publication: Springfield, Ill., Thomas.
مواضيع طبية MeSH:	Fontan Procedure* , Magnetic Resonance Imaging* , Tomography, X-Ray Computed* , Ultrasonography, Heart Defects, Congenital/surgery , Liver Diseases/*diagnostic imaging, Adult ; Cross-Sectional Studies ; Elasticity Imaging Techniques ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnostic imaging ; Humans ; Liver Diseases/complications ; Male ; Multimodal Imaging ; Predictive Value of Tests ; Young Adult
مستخلص:	Objective: Currently, there is no consensus in the literature regarding the screening of hepatic nodules in patients who have undergone the Fontan procedure. The objectives of this study are to evaluate in this population the frequency of hepatic nodules at ultrasound (US), CT, and MRI; to measure liver stiffness using acoustic radiation force impulse (ARFI) elastography; and to investigate predictive factors for hepatic nodules. Subjects and Methods: In this cross-sectional study, 49 patients who underwent the Fontan procedure were prospectively recruited from August 2014 through June 2016. These patients underwent clinical evaluation for hepatic disorders, ARFI elastography, US, CT, and MRI. Results: Most of the patients had no symptoms, and hepatic nodules were detected in three of 49 (6.1%) patients at US, 14 of 44 (31.8%) patients at CT, and 19 of 48 (39.6%) patients at MRI. Liver stiffness at ARFI elastography was significantly higher in patients with hepatic nodules than in patients without such nodules (2.64 ± 0.81 m/s vs 1.94 ± 0.49 m/s; p = 0.002) and was a significant predictor of hepatic nodule (AUC, 0.767; p = 0.002). No clinical or laboratory data had any significant correlation with the existence of hepatic nodules, including time since Fontan procedure. Conclusion: In our study, more than one-third of patients had hepatic nodules at CT or MRI, but US did not detect most hepatic nodules. Liver stiffness at ARFI elastography was significantly higher in patients with hepatic nodules, and it may help guiding which patient should be further imaged with CT or MRI.
فهرسة مساهمة:	Keywords: CT; Fontan procedure; MDCT; MRI; liver disease; ultrasound
تواريخ الأحداث:	Date Created: 20180925 Date Completed: 20190812 Latest Revision: 20190812
رمز التحديث:	20240628
DOI:	10.2214/AJR.18.19762
PMID:	30247977
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1546-3141
DOI:	10.2214/AJR.18.19762