دورية أكاديمية
Patients with multiple morphological abnormalities of the sperm flagella harbouring CFAP44 or CFAP43 mutations have a good pregnancy outcome following intracytoplasmic sperm injection.
| العنوان: | Patients with multiple morphological abnormalities of the sperm flagella harbouring CFAP44 or CFAP43 mutations have a good pregnancy outcome following intracytoplasmic sperm injection. |
|---|---|
| المؤلفون: | Sha YW; Department of Reproductive Medicine, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China., Wang X; Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China., Su ZY; Department of Reproductive Medicine, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China., Mei LB; Department of Reproductive Medicine, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China., Ji ZY; Department of Reproductive Medicine, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China., Bao H; Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China., Li P; Department of Reproductive Medicine, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China. |
| المصدر: | Andrologia [Andrologia] 2019 Feb; Vol. 51 (1), pp. e13151. Date of Electronic Publication: 2018 Sep 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0272 (Electronic) Linking ISSN: 03034569 NLM ISO Abbreviation: Andrologia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Berlin, Grosse |
| مواضيع طبية MeSH: | Mutation*, Fertilization/*physiology , Infertility, Male/*genetics , Microtubule Proteins/*genetics , Nuclear Proteins/*genetics , Peptide Hydrolases/*genetics , Sperm Tail/*physiology , Spermatozoa/*cytology, Adult ; Cell Shape/genetics ; Cytoskeletal Proteins ; Embryo Transfer ; Female ; Humans ; Male ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Sperm Injections, Intracytoplasmic |
| مستخلص: | Multiple morphological abnormalities of the sperm flagella (MMAF) are a rare type of male infertility. Mutations in DNAH1, CFAP43 and CFAP44 are the main aetiology of the disorder. Previously, good intracytoplasmic sperm injection (ICSI) outcomes were reported for MMAF patients with DNAH1 mutations. However, the ICSI prognosis for MMAF patients with CFAP43 or CFAP44 mutations was not known. We designed a retrospective cohort study. Molecular genetic testing identified six MMAF patients with biallelic CFAP44 (CFAP44 + group) or CFAP43 mutations and 12 patients with homozygous or compound heterozygous DNAH1 mutations (DNAH1 + group). A control group consisted of age-matched, non-MMAF men. For MMAF patients carrying CFAP44 mutations, the recorded rates of fertilisation, transferable embryos, pregnancy and delivery after ICSI were 76.47%, 88.46%, 50.0% and 50.0% respectively. The fertilisation rate was significantly higher in the CFAP44 + group than in the DNAH1 + group (76.47% vs. 54.5%, p = 0.0196). There were no statistically significant differences in the rates of transferable embryos, implantation, clinical pregnancy and miscarriage between the CFAP44 + group and either the DNAH1 + group or the age-matched control group. Our results support a good ICSI prognosis for MMAF patients carrying CFAP44 or CFAP43 mutations. (© 2018 Blackwell Verlag GmbH.) |
| معلومات مُعتمدة: | ZR2017LH012 Natural Science Foundation of Shandong Province; 2015-2-52 Youth Scientific Research Project of Fujian Provincial Health and Family Planning Commission; 2016-2-72 Youth Scientific Research Project of Fujian Provincial Health and Family Planning Commission; 2015D018 Science and Technology Project of Fujian Province; 2016D010 Science and Technology Project of Fujian Province; 2017D011 Science and Technology Project of Fujian Province; 3502Z20154033 Xiamen Science and Technology Planning Project; 3502Z20154035 Xiamen Science and Technology Planning Project; 2015-ZQN-JC-44 Young/Middle-aged Talent Cultivation Project; 2016WS0704 Medicine and Health Science Technology Development Project of Shandong Province; 3502Z20159022 Major/Important Disease Research Project |
| فهرسة مساهمة: | Keywords: CFAP43; CFAP44; intracytoplasmic sperm injection; multiple morphological abnormalities of the sperm flagella; pregnancy outcome |
| المشرفين على المادة: | 0 (CFAP43 protein, human) 0 (Cytoskeletal Proteins) 0 (Microtubule Proteins) 0 (Nuclear Proteins) EC 3.4.- (CFAP44 protein, human) EC 3.4.- (Peptide Hydrolases) |
| تواريخ الأحداث: | Date Created: 20180926 Date Completed: 20190423 Latest Revision: 20191210 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/and.13151 |
| PMID: | 30251428 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1439-0272 |
|---|---|
| DOI: | 10.1111/and.13151 |