Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.

التفاصيل البيبلوغرافية
العنوان:	Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.
المؤلفون:	Tsivgoulis G; Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN., Wilson D; Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom, New Zealand Brain Research Institute, Christchurch, New Zealand., Katsanos AH; Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Neurology, University of Ioannina School of Medicine, Ioannina, Greece., Sargento-Freitas J; Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Marques-Matos C; Department of Neurology, São João University Hospital Center, Porto, Portugal.; Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal., Azevedo E; Department of Neurology, São João University Hospital Center, Porto, Portugal.; Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal., Adachi T; Department of Neurology and General Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan., von der Brelie C; Department of Neurosurgery, Georg August University of Göttingen, Göttingen, Germany., Aizawa Y; Department of Research and Development, Tachikawa Medical Center, Nagaoka, Japan., Abe H; Department of Research and Development, Tachikawa Medical Center, Nagaoka, Japan., Tomita H; Department of Cardiology and Department of Hypertension and Stroke Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Okumura K; Advanced Arrhythmia Therapeutic Branch, Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan., Hagii J; Hirosaki Stroke and Rehabilitation Center, Hirosaki, Japan., Seiffge DJ; Stroke Center and Neurology, University Hospital and University of Basel, Basel, Switzerland., Lioutas VA; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Traenka C; Stroke Center and Neurology, University Hospital and University of Basel, Basel, Switzerland., Varelas P; Department of Neurology, Henry Ford Hospital, Detroit, MI., Basir G; Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada., Krogias C; Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany., Purrucker JC; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany., Sharma VK; Division of Neurology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Rizos T; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany., Mikulik R; International Clinical Research Center and Neurology Department, St Anne's Hospital and Masaryk University, Brno, Czech Republic., Sobowale OA; Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Barlinn K; Department of Neurology, Dresden Neurovascular Center, Dresden, Germany., Sallinen H; Department of Neurology, Helsinki University Hospital, Helsinki, Finland., Goyal N; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN., Yeh SJ; Stroke Center and Department of Neurology, National Taiwan University Hospital, Taiwan., Karapanayiotides T; Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Wu TY; Department of Neurology, Christchurch Hospital, Christchurch, New Zealand., Vadikolias K; Department of Neurology, Democritus University of Thrace, Alexandroupolis, Greece., Ferrigno M; Department of Neurology, Lille University, INSERM U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France., Hadjigeorgiou G; Department of Neurology, University of Thessaly, Larissa, Greece., Houben R; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands., Giannopoulos S; Department of Neurology, University of Ioannina School of Medicine, Ioannina, Greece., Schreuder FHBM; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands., Chang JJ; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN., Perry LA; Department of Neurosciences, Eastern Health, Melbourne, Victoria, Australia., Mehdorn M; Department of Neurosurgery, Georg August University of Göttingen, Göttingen, Germany., Marto JP; Neurology Department, Egas Moniz Hospital, West Lisbon Hospital Center, Lisbon, Portugal.; CEDOC, Nova Medical School, New University of Lisbon, Lisbon, Portugal., Pinho J; Department of Neurology, Braga Hospital, Braga, Portugal., Tanaka J; Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan., Boulanger M; Centre for Clinical Brain Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Al-Shahi Salman R; Centre for Clinical Brain Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Jäger HR; Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom., Shakeshaft C; Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom, New Zealand Brain Research Institute, Christchurch, New Zealand., Yakushiji Y; Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan., Choi PMC; Department of Neurosciences, Eastern Health, Melbourne, Victoria, Australia., Staals J; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands., Cordonnier C; Department of Neurology, Lille University, INSERM U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France., Jeng JS; Stroke Center and Department of Neurology, National Taiwan University Hospital, Taiwan., Veltkamp R; Division of Brain Sciences, Department of Stroke Medicine, Imperial College London, United Kingdom., Dowlatshahi D; Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada., Engelter ST; Stroke Center and Neurology, University Hospital and University of Basel, Basel, Switzerland.; Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging, Felix Platter Hospital, Basel, Switzerland., Parry-Jones AR; Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Meretoja A; Department of Neurology, Helsinki University Hospital, Helsinki, Finland.; Department of Medicine and Neurology at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Mitsias PD; Department of Neurology, Henry Ford Hospital, Detroit, MI.; Department of Neurology, School of Medicine, University of Crete, Crete, Greece., Alexandrov AV; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN., Ambler G; Department of Statistical Science, University College London, London, United Kingdom., Werring DJ; Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom, New Zealand Brain Research Institute, Christchurch, New Zealand.
المصدر:	Annals of neurology [Ann Neurol] 2018 Nov; Vol. 84 (5), pp. 694-704. Date of Electronic Publication: 2018 Oct 25.
نوع المنشور:	Journal Article; Meta-Analysis
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol
أسماء مطبوعة:	Publication: New York, NY : Wiley-Liss Original Publication: Boston, Little, Brown.
مواضيع طبية MeSH:	Anticoagulants/adverse effects , Cerebral Hemorrhage/chemically induced , Cerebral Hemorrhage/*pathology, Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Cerebral Hemorrhage/mortality ; Female ; Humans ; Male ; Middle Aged ; Neuroimaging ; Vitamin K/antagonists & inhibitors
مستخلص:	Objective: Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. Methods: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricular hemorrhage extension. Results: We included 7 eligible studies comprising 219 NOAC-ICH and 831 VKA-ICH patients (mean age = 77 years, 52.5% females). The 30-day mortality was similar between NOAC-ICH and VKA-ICH (24.3% vs 26.5%; hazard ratio = 0.94, 95% confidence interval [CI] = 0.67-1.31). However, in multivariate analyses adjusting for potential confounders, NOAC-ICH was associated with lower admission National Institutes of Health Stroke Scale (NIHSS) score (linear regression coefficient = -2.83, 95% CI = -5.28 to -0.38), lower likelihood of severe stroke (NIHSS > 10 points) on admission (odds ratio [OR] = 0.50, 95% CI = 0.30-0.84), and smaller baseline hematoma volume (linear regression coefficient = -0.24, 95% CI = -0.47 to -0.16). The two groups did not differ in the likelihood of baseline hematoma volume < 30cm ³ (OR = 1.14, 95% CI = 0.81-1.62), hematoma expansion (OR = 0.97, 95% CI = 0.63-1.48), in-hospital mortality (OR = 0.73, 95% CI = 0.49-1.11), functional status at discharge (common OR = 0.78, 95% CI = 0.57-1.07), or functional status at 3 months (common OR = 1.03, 95% CI = 0.75-1.43). Interpretation: Although functional outcome at discharge, 1 month, or 3 months was comparable after NOAC-ICH and VKA-ICH, patients with NOAC-ICH had smaller baseline hematoma volumes and less severe acute stroke syndromes. Ann Neurol 2018;84:702-712. (© 2018 American Neurological Association.)
معلومات مُعتمدة:	CS/18/2/33719 United Kingdom BHF_ British Heart Foundation; R380R/1114 United Kingdom DMT_ The Dunhill Medical Trust
المشرفين على المادة:	0 (Anticoagulants) 12001-79-5 (Vitamin K)
تواريخ الأحداث:	Date Created: 20180927 Date Completed: 20190819 Latest Revision: 20210109
رمز التحديث:	20231215
DOI:	10.1002/ana.25342
PMID:	30255970
قاعدة البيانات:	MEDLINE

View record at Wiley

Full Text Finder

الوصف
تدمد:	1531-8249
DOI:	10.1002/ana.25342